Programming by breast (BR) and formula (F) feeding and effects of a high cholesterol diet on bile acid metabolism

E. M. Jackson, T. J. Prihoda, G. E. Mott

Research output: Contribution to journalArticle

Abstract

To identify the metabolic basis of postweaning differences in bile acid synthesis (BAS) due to BRand F-feeding in baboons, we measured total BAS kinetically and hepatic microsomal activities of cholesterol 7α-hydroxylase (7α-OHase) and 27hydroxycholesterol 7α-hydroxylase (27OH-7α-OHase) by GLC-mass spectrometry. Of 6 baboons, 3 were BR-fed and 3 F-fed until 15 weeks. Measurements were made at 4 years of age on a low cholesterol chow diet and on a high cholesterol, saturated fat diet (HC-SF). BR-fed baboons had 74% higher total bile acid pool size (P < 0.03) and a 41% lower BAS (P= 0.11) compared with those fed F. Lower BAS among BR-fed animals was consistent with a 52% lower 7aOHase activity (P = NS). 27OH-7α-OHase activity was similar among BR- and F-fed animals. On the HC-SF diet, total BAS and 7o-OHase activities were 54% (P < 0.04) and 62% (P=NS) respectively of those measured on the chow diet. 27OH-7α-OHase activity was similar on the chow and HC-SF diets. These results suggest that programmed effects of BR- and F-feeding on BAS are mediated by effects on 7αOHase activity and feeding a HC-SF diet decreases BAS.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

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bile acids
high fat diet
Nutrition
Bile Acids and Salts
Metabolism
breasts
Breast
Cholesterol
Diet
metabolism
synthesis
diet
cholesterol
Papio
Fats
low cholesterol diet
Animals
Cholesterol 7-alpha-Hydroxylase
Mixed Function Oxygenases
Breast Feeding

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Programming by breast (BR) and formula (F) feeding and effects of a high cholesterol diet on bile acid metabolism. / Jackson, E. M.; Prihoda, T. J.; Mott, G. E.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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