Prognostic value of BHCG and local tumor invasion in stage I seminoma of the testis

Bradley F. Schwartz, Richard Auman, Samuel J. Peretsman, Judd W. Moul, George E. Deshon, Javier Hernandez, Thomas A. Rozanski, J. Brantley Thrasher

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Approximately 10-15% of patients with stage I pure seminoma of the testis have an elevated preorchiectomy serum beta human chorionic gonadotropin level [1-4]. The prognostic significance of this elevation is unknown. We performed a multi-institutional retrospective review of 332 men with stage I pure seminoma of the testis and evaluated the prognostic significance of this elevation and the prognostic value of local invasion of the primary tumor. Twenty-five of 191 evaluable patients (13%) had elevated preorchiectomy beta human chorionic gonadotropin. All normalized postoperatively and are alive without evidence of disease with a median follow-up of 50 months (range 1- 124 mo). Of 191 patients, 190 (99.5%) are alive and free of disease. One patient underwent salvage chemotherapy for a chest recurrence, and he is alive and free of disease at 72 months. We conclude that elevated preorchiectomy serum beta human chorionic gonadotropin level and local invasion of the primary tumor do not portend a poor prognosis in patients with clinical stage I pure seminoma of the testis.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalJournal of Surgical Oncology
Volume61
Issue number2
DOIs
StatePublished - Feb 1996

Keywords

  • beta human chorionic gonadotropin
  • radiotherapy
  • testicular cancer
  • tumor markers

ASJC Scopus subject areas

  • Surgery
  • Oncology

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