Prognostic Impact of QRS Axis Deviation in Patients Treated with Cardiac Resynchronization Therapy

Laura Perrotta, Jagdesh Kandala, Luigi Di Biase, Alessandro Valleggi, Federica Michelotti, Paolo Pieragnoli, Giuseppe Ricciardi, Giosuè Mascioli, Dhanunjaya Lakkireddy, Jayasree Pillarisetti, Michele Emdin, Andrea Natale, Jagmeet P. Singh, Luigi Padeletti

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Prognosis of QRS Axis Deviation in CRT-D Introduction QRS duration and morphology are currently recognized as recommended criteria for the selection of CRT candidates. It has recently been shown that patients with left bundle branch block (LBBB) derive substantial clinical benefit from CRT. The aim of this study is to investigate the prognostic impact of QRS axis deviation (AD) in HF patients with LBBB undergoing CRT. Methods and Results We retrospectively evaluated 707 HF patients with LBBB who underwent CRT at five centers. Baseline QRS axis was defined as normal (NA: -30° to 90°), right axis deviation (RAD: 90° to 180°) and left axis deviation (LAD: <-30°). The primary endpoint was a composite of all cause death/HF hospitalization. The risk of endpoint by AD was evaluated with both Kaplan-Meier and Cox proportional hazard analysis. Among 707 patients (73% M, median age: 71 [62,77] years), 323 (46%) had NA, 359 (51%) LAD, and 25 (3.5%) RAD. Baseline clinical characteristics were similar between the three groups. Over a mean follow-up of 32 ± 25 months, 141 deaths occurred (21%) and 36% (n = 255) met with the composite endpoint. A significantly higher proportion of RAD patients (52%) reached the endpoint (LAD 40%, NA 30%). KM analysis showed that RAD and LAD patients had worse event free survival and in multivariate analysis both LAD (HR: 1.40; 95% CI: 1.05-1.86; P = 0.021) and RAD (HR: 2.49; 95% CI: 1.31-4.74; P = 0.005) were independently associated with worse clinical outcome. Conclusions Right or left axis deviation in the presence of LBBB in HF patients undergoing CRT are independent predictors of poor prognosis.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Issue number3
StatePublished - Mar 1 2016
Externally publishedYes


  • QRS axis deviation
  • cardiac resynchronization therapy
  • heart failure
  • left bundle branch block

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Prognostic Impact of QRS Axis Deviation in Patients Treated with Cardiac Resynchronization Therapy'. Together they form a unique fingerprint.

Cite this