Prognostic factors and therapeutic decisions in axillary node-negative breast cancer

Richard M. Elledge; William L. McGuire

doi:10.1146/annurev.me.44.020193.001221

Prognostic factors and therapeutic decisions in axillary node-negative breast cancer

Richard M. Elledge, William L. McGuire

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

The incidence of node-negative breast cancer is increasing, and it is becoming a more commonly encountered clinical problem. Prognostic factors such as tumor size, histopathological characteristics, receptor status, proliferative markers, biochemical alterations, and gene abnormalities can be useful in assessing the risk of cancer recurrence after primary local therapy. By accurately assessing the risk of recurrence, informed decisions can be made about whether or not to treat with adjuvant systemic therapy.

Original language	English (US)
Pages (from-to)	201-210
Number of pages	10
Journal	Annual review of medicine
Volume	44
DOIs	https://doi.org/10.1146/annurev.me.44.020193.001221
State	Published - 1993
Externally published	Yes

Keywords

breast cancer
histology
p53 gene
prognostic factors
therapy

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1146/annurev.me.44.020193.001221

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abstract = "The incidence of node-negative breast cancer is increasing, and it is becoming a more commonly encountered clinical problem. Prognostic factors such as tumor size, histopathological characteristics, receptor status, proliferative markers, biochemical alterations, and gene abnormalities can be useful in assessing the risk of cancer recurrence after primary local therapy. By accurately assessing the risk of recurrence, informed decisions can be made about whether or not to treat with adjuvant systemic therapy.",

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AU - Elledge, Richard M.

AU - McGuire, William L.

PY - 1993

Y1 - 1993

N2 - The incidence of node-negative breast cancer is increasing, and it is becoming a more commonly encountered clinical problem. Prognostic factors such as tumor size, histopathological characteristics, receptor status, proliferative markers, biochemical alterations, and gene abnormalities can be useful in assessing the risk of cancer recurrence after primary local therapy. By accurately assessing the risk of recurrence, informed decisions can be made about whether or not to treat with adjuvant systemic therapy.

AB - The incidence of node-negative breast cancer is increasing, and it is becoming a more commonly encountered clinical problem. Prognostic factors such as tumor size, histopathological characteristics, receptor status, proliferative markers, biochemical alterations, and gene abnormalities can be useful in assessing the risk of cancer recurrence after primary local therapy. By accurately assessing the risk of recurrence, informed decisions can be made about whether or not to treat with adjuvant systemic therapy.

KW - breast cancer

KW - histology

KW - p53 gene

KW - prognostic factors

KW - therapy

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JF - Annual Review of Medicine

ER -

Prognostic factors and therapeutic decisions in axillary node-negative breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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