Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilation

Eva Tejerina, Fernando Frutos-Vivar, Marcos Restrepo, Antonio R Anzueto, Fernando Palizas, Marco González, Carlos Apezteguía, Fekri Abroug, Dimitros Matamis, Guillermo Bugedo, Andrés Esteban

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: To evaluate the variables associated with mortality of patients with community-acquired pneumonia who require mechanical ventilation and to determine the attributable morbidity and intensive care unit (ICU) mortality of community-acquired pneumonia. Material and Methods: Retrospective cohort study carried out in 361 ICUs from 20 countries including 124 patients who required mechanical ventilation on the first day of admission to the hospital due to acute respiratory failure secondary to severe community-acquired pneumonia. To assess the factors associated with outcome, a forward stepwise logistic regression analysis was performed, and to determine the attributable mortality of community-acquired pneumonia, a matched study design was used. Results: We found 3 independent variables significantly associated with death in patients with community-acquired pneumonia requiring mechanical ventilation: simplified acute physiological score greater than 45 (odds ratio, 5.5 [95% confidence interval, 1.7-12.3]), shock (odds ratio, 5.7 [95% confidence interval, 1.7-10.1]), and acute renal failure (odds ratio, 3.0 [95% confidence interval, 1.1-4.0]). There was no statistically significant difference in ICU mortality among patients with or without community-acquired pneumonia (32% vs 35%; P = .59). Conclusions: Community-acquired pneumonia needing mechanical ventilation is not a disease associated with higher mortality. The main determinants of patient outcome were initial severity of illness and the development of shock and/or acute renal failure.

Original languageEnglish (US)
Pages (from-to)230-238
Number of pages9
JournalJournal of Critical Care
Volume20
Issue number3
DOIs
StatePublished - Sep 2005

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Artificial Respiration
Pneumonia
Mortality
Odds Ratio
Confidence Intervals
Acute Kidney Injury
Intensive Care Units
Shock
Respiratory Insufficiency
Cohort Studies
Retrospective Studies
Logistic Models
Regression Analysis
Morbidity

Keywords

  • Community-acquired pneumonia
  • Intensive care unit
  • Mechanical ventilation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilation. / Tejerina, Eva; Frutos-Vivar, Fernando; Restrepo, Marcos; Anzueto, Antonio R; Palizas, Fernando; González, Marco; Apezteguía, Carlos; Abroug, Fekri; Matamis, Dimitros; Bugedo, Guillermo; Esteban, Andrés.

In: Journal of Critical Care, Vol. 20, No. 3, 09.2005, p. 230-238.

Research output: Contribution to journalArticle

Tejerina, E, Frutos-Vivar, F, Restrepo, M, Anzueto, AR, Palizas, F, González, M, Apezteguía, C, Abroug, F, Matamis, D, Bugedo, G & Esteban, A 2005, 'Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilation', Journal of Critical Care, vol. 20, no. 3, pp. 230-238. https://doi.org/10.1016/j.jcrc.2005.05.010
Tejerina, Eva ; Frutos-Vivar, Fernando ; Restrepo, Marcos ; Anzueto, Antonio R ; Palizas, Fernando ; González, Marco ; Apezteguía, Carlos ; Abroug, Fekri ; Matamis, Dimitros ; Bugedo, Guillermo ; Esteban, Andrés. / Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilation. In: Journal of Critical Care. 2005 ; Vol. 20, No. 3. pp. 230-238.
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