Progesterone and 17α-hydroxyprogesterone advance the estrogen-induced bioassayable luteinizing hormone surge in castrate monkeys

R. S. Schenken; R. F. Williams; B. D. Cowan; G. D. Hodgen

doi:10.1016/s0015-0282(16)48390-1

Progesterone and 17α-hydroxyprogesterone advance the estrogen-induced bioassayable luteinizing hormone surge in castrate monkeys

R. S. Schenken, R. F. Williams, B. D. Cowan, G. D. Hodgen

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Recent studies have demonstrated marked disparities between bioassayable (BIO) versus radioimmunoassayable concentrations of luteinizing hormone (LH) at midcyle. Other studies in intact women and monkeys have indicated that progesterone (P) may facilitate estrogen induction of the preovulatory gonadotropin surges. We have combined the study of these observations as follows: long-term castrate female monkeys were given estradiol benzoate with and without subsequent P or 17α-hydroxyprogesterone (17-OHP) injections. Plasma was collected during a selected 24-hour interval via a chronic indwelling femoral vein cannula. Initially, estrogen-negative feedback decreased the pulsatility and circulating levels of gonadotropins. P and 17-OHP treatment (after estradiol) hastened initiation of the BIO-LH surge by up to 8 hours. Although estrogen-positive feedback alone enhanced the biologic activity of LH, P and 17-OHP expedited the midcycle-like BIO-LH surges.

Original language	English (US)
Pages (from-to)	301-307
Number of pages	7
Journal	Fertility and sterility
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/s0015-0282(16)48390-1
State	Published - 1985

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Progesterone and 17α-hydroxyprogesterone advance the estrogen-induced bioassayable luteinizing hormone surge in castrate monkeys",

abstract = "Recent studies have demonstrated marked disparities between bioassayable (BIO) versus radioimmunoassayable concentrations of luteinizing hormone (LH) at midcyle. Other studies in intact women and monkeys have indicated that progesterone (P) may facilitate estrogen induction of the preovulatory gonadotropin surges. We have combined the study of these observations as follows: long-term castrate female monkeys were given estradiol benzoate with and without subsequent P or 17α-hydroxyprogesterone (17-OHP) injections. Plasma was collected during a selected 24-hour interval via a chronic indwelling femoral vein cannula. Initially, estrogen-negative feedback decreased the pulsatility and circulating levels of gonadotropins. P and 17-OHP treatment (after estradiol) hastened initiation of the BIO-LH surge by up to 8 hours. Although estrogen-positive feedback alone enhanced the biologic activity of LH, P and 17-OHP expedited the midcycle-like BIO-LH surges.",

author = "Schenken, {R. S.} and Williams, {R. F.} and Cowan, {B. D.} and Hodgen, {G. D.}",

year = "1985",

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AU - Schenken, R. S.

AU - Williams, R. F.

AU - Cowan, B. D.

AU - Hodgen, G. D.

PY - 1985

Y1 - 1985

N2 - Recent studies have demonstrated marked disparities between bioassayable (BIO) versus radioimmunoassayable concentrations of luteinizing hormone (LH) at midcyle. Other studies in intact women and monkeys have indicated that progesterone (P) may facilitate estrogen induction of the preovulatory gonadotropin surges. We have combined the study of these observations as follows: long-term castrate female monkeys were given estradiol benzoate with and without subsequent P or 17α-hydroxyprogesterone (17-OHP) injections. Plasma was collected during a selected 24-hour interval via a chronic indwelling femoral vein cannula. Initially, estrogen-negative feedback decreased the pulsatility and circulating levels of gonadotropins. P and 17-OHP treatment (after estradiol) hastened initiation of the BIO-LH surge by up to 8 hours. Although estrogen-positive feedback alone enhanced the biologic activity of LH, P and 17-OHP expedited the midcycle-like BIO-LH surges.

AB - Recent studies have demonstrated marked disparities between bioassayable (BIO) versus radioimmunoassayable concentrations of luteinizing hormone (LH) at midcyle. Other studies in intact women and monkeys have indicated that progesterone (P) may facilitate estrogen induction of the preovulatory gonadotropin surges. We have combined the study of these observations as follows: long-term castrate female monkeys were given estradiol benzoate with and without subsequent P or 17α-hydroxyprogesterone (17-OHP) injections. Plasma was collected during a selected 24-hour interval via a chronic indwelling femoral vein cannula. Initially, estrogen-negative feedback decreased the pulsatility and circulating levels of gonadotropins. P and 17-OHP treatment (after estradiol) hastened initiation of the BIO-LH surge by up to 8 hours. Although estrogen-positive feedback alone enhanced the biologic activity of LH, P and 17-OHP expedited the midcycle-like BIO-LH surges.

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Progesterone and 17α-hydroxyprogesterone advance the estrogen-induced bioassayable luteinizing hormone surge in castrate monkeys

Abstract

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