Production of macrophage inhibition factor by rat lymphocytes following exposure to isologous liver subcellular membranes

Robert T. McCalmon; R. Neal Pinckard; Merle S. Olson

doi:10.1016/0090-1229(75)90079-3

Production of macrophage inhibition factor by rat lymphocytes following exposure to isologous liver subcellular membranes

Robert T. McCalmon, R. Neal Pinckard, Merle S. Olson

Research output: Contribution to journal › Article › peer-review

Abstract

Direct inhibition of marcophage migration occurred when rat peritoneal exudate cells obtained from syngeneic Lewis rats were incubated with isologous rat liver membranous subcellular constituents. Subcellular membranes also induced the release of a migration inhibition factor (MIF) from isologous lymph node cells. Mitogenic activity was not detected upon incubation of lymph node cells with subcellular membranes. However, both the mitochondria-induced direct inhibition of macrophage migration and the production of MIF by lymph node cells were shown to be thymic dependent.

Original language	English (US)
Pages (from-to)	541-554
Number of pages	14
Journal	Clinical Immunology and Immunopathology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0090-1229(75)90079-3
State	Published - Mar 1975
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(75)90079-3

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title = "Production of macrophage inhibition factor by rat lymphocytes following exposure to isologous liver subcellular membranes",

abstract = "Direct inhibition of marcophage migration occurred when rat peritoneal exudate cells obtained from syngeneic Lewis rats were incubated with isologous rat liver membranous subcellular constituents. Subcellular membranes also induced the release of a migration inhibition factor (MIF) from isologous lymph node cells. Mitogenic activity was not detected upon incubation of lymph node cells with subcellular membranes. However, both the mitochondria-induced direct inhibition of macrophage migration and the production of MIF by lymph node cells were shown to be thymic dependent.",

author = "McCalmon, {Robert T.} and Pinckard, {R. Neal} and Olson, {Merle S.}",

note = "Funding Information: We wish to thank Mr. David study. This work was supported and AI-00372) and the Arizona L. May for his assistance by grants from the United Heart Association.",

year = "1975",

month = mar,

doi = "10.1016/0090-1229(75)90079-3",

language = "English (US)",

volume = "3",

pages = "541--554",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

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TY - JOUR

T1 - Production of macrophage inhibition factor by rat lymphocytes following exposure to isologous liver subcellular membranes

AU - McCalmon, Robert T.

AU - Pinckard, R. Neal

AU - Olson, Merle S.

N1 - Funding Information: We wish to thank Mr. David study. This work was supported and AI-00372) and the Arizona L. May for his assistance by grants from the United Heart Association.

PY - 1975/3

Y1 - 1975/3

N2 - Direct inhibition of marcophage migration occurred when rat peritoneal exudate cells obtained from syngeneic Lewis rats were incubated with isologous rat liver membranous subcellular constituents. Subcellular membranes also induced the release of a migration inhibition factor (MIF) from isologous lymph node cells. Mitogenic activity was not detected upon incubation of lymph node cells with subcellular membranes. However, both the mitochondria-induced direct inhibition of macrophage migration and the production of MIF by lymph node cells were shown to be thymic dependent.

AB - Direct inhibition of marcophage migration occurred when rat peritoneal exudate cells obtained from syngeneic Lewis rats were incubated with isologous rat liver membranous subcellular constituents. Subcellular membranes also induced the release of a migration inhibition factor (MIF) from isologous lymph node cells. Mitogenic activity was not detected upon incubation of lymph node cells with subcellular membranes. However, both the mitochondria-induced direct inhibition of macrophage migration and the production of MIF by lymph node cells were shown to be thymic dependent.

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SN - 0090-1229

VL - 3

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EP - 554

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 4

ER -

Production of macrophage inhibition factor by rat lymphocytes following exposure to isologous liver subcellular membranes

Abstract

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