Abstract
We constructed an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus. Upon transfection, this clone directed the production of infectious virus particles in a wide variety of cells in addition to human T4 cells. The progeny, infectious virions, were synthesized in mouse, mink, monkey, and several human non-T cell lines, indicating the absence of any intracellular obstacle to viral RNA or protein production or assembly. During the course of these studies, a human colon carcinoma cell line, exquisitely sensitive to DNA transfection, was identified.
Original language | English (US) |
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Pages (from-to) | 284-291 |
Number of pages | 8 |
Journal | Journal of Virology |
Volume | 59 |
Issue number | 2 |
State | Published - Nov 19 1986 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology