Prodromal symptoms and signs of bipolar relapse: A report based on prospectively collected data

Emily S. Altman; Margaret M. Rea; Jim Mintz; David J. Miklowitz; Michael J. Goldstein; Sun Hwang

doi:10.1016/0165-1781(92)90012-R

Prodromal symptoms and signs of bipolar relapse: A report based on prospectively collected data

Emily S. Altman, Margaret M. Rea, Jim Mintz, David J. Miklowitz, Michael J. Goldstein, Sun Hwang

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Psychiatry Research
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(92)90012-R
State	Published - Jan 1992
Externally published	Yes

Keywords

Brief Psychiatric Rating Scale
Manic-depression
prodrome
recurrence

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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abstract = "Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.",

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