Prodromal symptoms and signs of bipolar relapse: A report based on prospectively collected data

Emily S. Altman; Margaret M. Rea; Jim Mintz; David J. Miklowitz; Michael J. Goldstein; Sun Hwang

doi:10.1016/0165-1781(92)90012-R

Prodromal symptoms and signs of bipolar relapse: A report based on prospectively collected data

Emily S. Altman, Margaret M. Rea, Jim Mintz, David J. Miklowitz, Michael J. Goldstein, Sun Hwang

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Psychiatry Research
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(92)90012-R
State	Published - Jan 1992
Externally published	Yes

Keywords

Brief Psychiatric Rating Scale
Manic-depression
prodrome
recurrence

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(92)90012-R

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title = "Prodromal symptoms and signs of bipolar relapse: A report based on prospectively collected data",

abstract = "Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.",

keywords = "Brief Psychiatric Rating Scale, Manic-depression, prodrome, recurrence",

author = "Altman, {Emily S.} and Rea, {Margaret M.} and Jim Mintz and Miklowitz, {David J.} and Goldstein, {Michael J.} and Sun Hwang",

note = "Funding Information: second authors funded by an NIMH NRSA Training Grant MH-14584, NIMH research grants MH-08744, MH-33758, and MH-30833, a grant from the John T. and Catherine MacArthur Foundation on Risk and Protective Factors in the Major Mental Disorders, and a grant from the National Alliance for Research in Schizophrenia and Depression. The authors thank Wilfred J. Dixon, Ph.D., Robert Gerner, M.D., Michael Gitlin, M.D., David Lukoff, Ph.D., Sandra Malik, Steven Marder, M.D., Keith Nuechterlein, Ph.D., and Joseph Ventura, M.A., for their invaluable assistancew ith this research.",

year = "1992",

month = jan,

doi = "10.1016/0165-1781(92)90012-R",

language = "English (US)",

volume = "41",

pages = "1--8",

journal = "Psychiatry Research",

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T1 - Prodromal symptoms and signs of bipolar relapse

T2 - A report based on prospectively collected data

AU - Altman, Emily S.

AU - Rea, Margaret M.

AU - Mintz, Jim

AU - Miklowitz, David J.

AU - Goldstein, Michael J.

AU - Hwang, Sun

N1 - Funding Information: second authors funded by an NIMH NRSA Training Grant MH-14584, NIMH research grants MH-08744, MH-33758, and MH-30833, a grant from the John T. and Catherine MacArthur Foundation on Risk and Protective Factors in the Major Mental Disorders, and a grant from the National Alliance for Research in Schizophrenia and Depression. The authors thank Wilfred J. Dixon, Ph.D., Robert Gerner, M.D., Michael Gitlin, M.D., David Lukoff, Ph.D., Sandra Malik, Steven Marder, M.D., Keith Nuechterlein, Ph.D., and Joseph Ventura, M.A., for their invaluable assistancew ith this research.

PY - 1992/1

Y1 - 1992/1

N2 - Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.

AB - Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.

KW - Brief Psychiatric Rating Scale

KW - Manic-depression

KW - prodrome

KW - recurrence

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Prodromal symptoms and signs of bipolar relapse: A report based on prospectively collected data

Abstract

Keywords

ASJC Scopus subject areas

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