TY - JOUR
T1 - Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging
AU - Kochunov, P.
AU - Coyle, T.
AU - Lancaster, J.
AU - Robin, Donald A
AU - Hardies, J.
AU - Kochunov, V.
AU - Bartzokis, G.
AU - Stanley, J.
AU - Royall, D.
AU - Schlosser, A. E.
AU - Null, M.
AU - Fox, P. T.
N1 - Funding Information:
This research was supported by National Institute of Biomedical Imaging and Bioengineering ( K01 EB006395 ) grant to P.K.; Research support was also provided by the Human Brain Mapping Project, which is jointly funded by NIMH and NIDA (P20 MH/DA52176), by General Clinical Research Core (HSC19940074H) and San Antonio Area Foundation.
PY - 2010/1/15
Y1 - 2010/1/15
N2 - We explored relationships between decline in cognitive processing speed (CPS) and change in frontal lobe MRI/MRS-based indices of cerebral integrity in 38 healthy adults (age 57-90 years). CPS was assessed using a battery of four timed neuropsychological tests: Grooved Pegboard, Coding, Symbol Digit Modalities Test and Category Fluency (Fruits and Furniture). The neuropsychological tests were factor analyzed to extract two components of CPS: psychomotor (PM) and psychophysical (PP). MRI-based indices of cerebral integrity included three cortical measurements per hemisphere (GM thickness, intergyral and sulcal spans) and two subcortical indices (fractional anisotropy (FA), measured using track-based spatial statistics (TBSS), and the volume of hyperintense WM (HWM)). MRS indices included levels of choline-containing compounds (GPC + PC), phosphocreatine plus creatine (PCr + Cr), and N-acetylaspartate (NAA), measured bilaterally in the frontal WM bundles. A substantial fraction of the variance in the PM-CPS (58%) was attributed to atrophic changes in frontal WM, observed as increases in sulcal span, declines in FA values and reductions in concentrations of NAA and choline-containing compounds. A smaller proportion (20%) of variance in the PP-CPS could be explained by bilateral increases in frontal sulcal span and increases in HWM volumes.
AB - We explored relationships between decline in cognitive processing speed (CPS) and change in frontal lobe MRI/MRS-based indices of cerebral integrity in 38 healthy adults (age 57-90 years). CPS was assessed using a battery of four timed neuropsychological tests: Grooved Pegboard, Coding, Symbol Digit Modalities Test and Category Fluency (Fruits and Furniture). The neuropsychological tests were factor analyzed to extract two components of CPS: psychomotor (PM) and psychophysical (PP). MRI-based indices of cerebral integrity included three cortical measurements per hemisphere (GM thickness, intergyral and sulcal spans) and two subcortical indices (fractional anisotropy (FA), measured using track-based spatial statistics (TBSS), and the volume of hyperintense WM (HWM)). MRS indices included levels of choline-containing compounds (GPC + PC), phosphocreatine plus creatine (PCr + Cr), and N-acetylaspartate (NAA), measured bilaterally in the frontal WM bundles. A substantial fraction of the variance in the PM-CPS (58%) was attributed to atrophic changes in frontal WM, observed as increases in sulcal span, declines in FA values and reductions in concentrations of NAA and choline-containing compounds. A smaller proportion (20%) of variance in the PP-CPS could be explained by bilateral increases in frontal sulcal span and increases in HWM volumes.
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U2 - 10.1016/j.neuroimage.2009.09.052
DO - 10.1016/j.neuroimage.2009.09.052
M3 - Article
C2 - 19796691
AN - SCOPUS:70849116060
SN - 1053-8119
VL - 49
SP - 1190
EP - 1199
JO - NeuroImage
JF - NeuroImage
IS - 2
ER -