Procedure for minimizing stress for fMRI studies in conscious rats

Jean A. King, Timothy S. Garelick, Mathew E. Brevard, Wei Chen, Tara L. Messenger, Timothy Q. Duong, Craig F. Ferris

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented.

Original languageEnglish (US)
Pages (from-to)154-160
Number of pages7
JournalJournal of Neuroscience Methods
Volume148
Issue number2
DOIs
StatePublished - Oct 30 2005

Keywords

  • Blood pressure
  • HPA axis
  • Heart rate
  • Imaging
  • Restraint stress
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    King, J. A., Garelick, T. S., Brevard, M. E., Chen, W., Messenger, T. L., Duong, T. Q., & Ferris, C. F. (2005). Procedure for minimizing stress for fMRI studies in conscious rats. Journal of Neuroscience Methods, 148(2), 154-160. https://doi.org/10.1016/j.jneumeth.2005.04.011