Probing biomolecular structure, dynamics, and function using hydrogen exchange

Research output: Contribution to journalReview articlepeer-review


This commentary highlights the landmark manuscript published in 1957 by Arieh Berger and K. Linderstrøm-Lang that describes the measurement and analysis of hydrogen exchange rates. This highly referenced manuscript is recognized because the impact hydrogen exchange has had on characterizing the structure and dynamics of natively folded proteins and folding intermediates.

Original languageEnglish (US)
Article number109185
JournalArchives of Biochemistry and Biophysics
StateAccepted/In press - 2022
Externally publishedYes


  • HDX-MS
  • Hydrogen exchange
  • NMR
  • Protein dynamics
  • Protein stability

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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