Abstract
Electric-field induced physical phenomena, such as thermal, mechanical and electrochemical dynamics, may be the driving mechanism behind bioeffects observed in mammalian cells during exposure to nanosecond-duration electric pulses (nsEP) in-vitro. Correlating a driving mechanism to a biological response requires the experimental measurement and quantification of all physical dynamics resulting from the nsEP stimulus. A passive and electromagnetic interference (EMI) immune sensor is required to resolve these dynamics in high strength electric fields. The probe beam deflection technique (PBDT) is a passive and EMI immune optical method for quantifying and imaging refractive index gradients in liquids and gases, both dynamic and static, with nanosecond temporal resolution. In this work, a probe beam deflection imaging system was designed to acquire 2-D time-lapse images of thermal/mechanical dynamics resulting from monopolar and bipolar nsEP stimulus.
Original language | English (US) |
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Pages (from-to) | 6621-6643 |
Number of pages | 23 |
Journal | Optics Express |
Volume | 25 |
Issue number | 6 |
DOIs | |
State | Published - Mar 20 2017 |
Externally published | Yes |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics