Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study

on behalf of the PCORnet Antibiotics and Childhood Growth Study Group

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Privacy-protecting analytic approaches without centralized pooling of individual-level data, such as distributed regression, are particularly important for vulnerable populations, such as children, but these methods have not yet been tested in multi-center pediatric studies. Methods: Using the electronic health data from 34 healthcare institutions in the National Patient-Centered Clinical Research Network (PCORnet), we fit 12 multivariable-adjusted linear regression models to assess the associations of antibiotic use <24 months of age with body mass index z-score at 48 to <72 months of age. We ran these models using pooled individual-level data and conventional multivariable-adjusted regression (reference method), as well as using the more privacy-protecting pooled summary-level intermediate statistics and distributed regression technique. We compared the results from these two methods. Results: Pooled individual-level and distributed linear regression analyses produced virtually identical parameter estimates and standard errors. Across all 12 models, the maximum difference in any of the parameter estimates or standard errors was 4.4833 × 10−10. Conclusions: We demonstrated empirically the feasibility and validity of distributed linear regression analysis using only summary-level information within a large multi-center study of children. This approach could enable expanded opportunities for multi-center pediatric research, especially when sharing of granular individual-level data is challenging.

Original languageEnglish (US)
Pages (from-to)1086-1092
Number of pages7
JournalPediatric Research
Issue number6
StatePublished - May 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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