Principles of pharmacogenomics: Pharmacokinetic, pharmacodynamic, and clinical implications

Y. W.Francis Lam

doi:10.1016/B978-0-12-812626-4.00001-2

Principles of pharmacogenomics: Pharmacokinetic, pharmacodynamic, and clinical implications

Y. W.Francis Lam

Department of Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

Response to drug therapy varies considerably among individuals. Variations in genes involved in drug disposition, and in eliciting drug response significantly contribute to interpatient variability in drug response. Pharmacogenomics involves the search for genetic variations influencing drug response and offers the opportunity to improve drug effectiveness and safety through a personalized approach to drug prescribing. In addition to potentially improving the use of existing therapies, pharmacogenetics has led to the development of novel drugs based on an improved understanding of genetic contributions to disease pathophysiology.

Original language	English (US)
Title of host publication	Pharmacogenomics
Subtitle of host publication	Challenges and Opportunities in Therapeutic Implementation
Publisher	Elsevier
Pages	1-53
Number of pages	53
ISBN (Electronic)	9780128126264
DOIs	https://doi.org/10.1016/B978-0-12-812626-4.00001-2
State	Published - Jan 1 2018

Keywords

Adverse drug reactions
Drug response
Enzymes
Ethnic heterogeneity
Pharmacogenetics
Pharmacogenomics
Single-nucleotide polymorphism
Therapeutic response
Transporters targets

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Medicine

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10.1016/B978-0-12-812626-4.00001-2

Cite this

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KW - Adverse drug reactions

KW - Drug response

KW - Enzymes

KW - Ethnic heterogeneity

KW - Pharmacogenetics

KW - Pharmacogenomics

KW - Single-nucleotide polymorphism

KW - Therapeutic response

KW - Transporters targets

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PB - Elsevier

ER -

Principles of pharmacogenomics: Pharmacokinetic, pharmacodynamic, and clinical implications

Abstract

Keywords

ASJC Scopus subject areas

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