Principles of pharmacogenomics: Pharmacokinetic, pharmacodynamic, and clinical implications

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Response to drug therapy varies considerably among individuals. Variations in genes involved in drug disposition, and in eliciting drug response significantly contribute to interpatient variability in drug response. Pharmacogenomics involves the search for genetic variations influencing drug response and offers the opportunity to improve drug effectiveness and safety through a personalized approach to drug prescribing. In addition to potentially improving the use of existing therapies, pharmacogenetics has led to the development of novel drugs based on an improved understanding of genetic contributions to disease pathophysiology.

Original languageEnglish (US)
Title of host publicationPharmacogenomics
Subtitle of host publicationChallenges and Opportunities in Therapeutic Implementation
PublisherElsevier
Pages1-53
Number of pages53
ISBN (Electronic)9780128126264
DOIs
StatePublished - Jan 1 2018

Keywords

  • Adverse drug reactions
  • Drug response
  • Enzymes
  • Ethnic heterogeneity
  • Pharmacogenetics
  • Pharmacogenomics
  • Single-nucleotide polymorphism
  • Therapeutic response
  • Transporters targets

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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