Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

Y. W.Francis Lam, Larisa H. Cavallari

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Response to drug therapy varies considerably among individuals. Variations in genes involved in drug disposition and in eliciting drug response significantly contribute to the interpatient variability in drug response. Pharmacogenomics involves the search for genetic variations influencing drug response and offers the opportunity to improve drug effectiveness and safety through a personalized approach to drug prescribing. In addition to potentially improving the use of existing therapies, pharmacogenetics has led to the development of novel drugs based on an improved understanding of genetic contributions to disease pathophysiology.This chapter provides an overview of variation in the human genome and how this variation influences drug pharmacokinetics and pharmacodynamics, thus affecting drug response. © 2013

Original languageEnglish (US)
Title of host publicationPharmacogenomics
PublisherElsevier Inc.
Pages1-44
Number of pages44
ISBN (Print)9780123919182
DOIs
StatePublished - Aug 27 2013

Keywords

  • Drug metabolizing enzymes
  • Gene polymorphisms
  • Pharmacogenomics
  • Targets
  • Transporters

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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