Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

Y. W.Francis Lam; Larisa H. Cavallari

doi:10.1016/B978-0-12-391918-2.00001-9

Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

Y. W.Francis Lam, Larisa H. Cavallari

Department of Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Response to drug therapy varies considerably among individuals. Variations in genes involved in drug disposition and in eliciting drug response significantly contribute to the interpatient variability in drug response. Pharmacogenomics involves the search for genetic variations influencing drug response and offers the opportunity to improve drug effectiveness and safety through a personalized approach to drug prescribing. In addition to potentially improving the use of existing therapies, pharmacogenetics has led to the development of novel drugs based on an improved understanding of genetic contributions to disease pathophysiology.This chapter provides an overview of variation in the human genome and how this variation influences drug pharmacokinetics and pharmacodynamics, thus affecting drug response. © 2013

Original language	English (US)
Title of host publication	Pharmacogenomics
Publisher	Elsevier Inc.
Pages	1-44
Number of pages	44
ISBN (Print)	9780123919182
DOIs	https://doi.org/10.1016/B978-0-12-391918-2.00001-9
State	Published - 2013

Keywords

Drug metabolizing enzymes
Gene polymorphisms
Pharmacogenomics
Targets
Transporters

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmacology

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10.1016/B978-0-12-391918-2.00001-9

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AB - Response to drug therapy varies considerably among individuals. Variations in genes involved in drug disposition and in eliciting drug response significantly contribute to the interpatient variability in drug response. Pharmacogenomics involves the search for genetic variations influencing drug response and offers the opportunity to improve drug effectiveness and safety through a personalized approach to drug prescribing. In addition to potentially improving the use of existing therapies, pharmacogenetics has led to the development of novel drugs based on an improved understanding of genetic contributions to disease pathophysiology.This chapter provides an overview of variation in the human genome and how this variation influences drug pharmacokinetics and pharmacodynamics, thus affecting drug response. © 2013

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KW - Gene polymorphisms

KW - Pharmacogenomics

KW - Targets

KW - Transporters

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PB - Elsevier Inc.

ER -

Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

Abstract

Keywords

ASJC Scopus subject areas

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