Abstract
Response to drug therapy varies considerably among individuals. Variations in genes involved in drug disposition and in eliciting drug response significantly contribute to the interpatient variability in drug response. Pharmacogenomics involves the search for genetic variations influencing drug response and offers the opportunity to improve drug effectiveness and safety through a personalized approach to drug prescribing. In addition to potentially improving the use of existing therapies, pharmacogenetics has led to the development of novel drugs based on an improved understanding of genetic contributions to disease pathophysiology. This chapter provides an overview of variation in the human genome and how this variation influences drug pharmacokinetics and pharmacodynamics, thus affecting drug response.
| Original language | English (US) |
|---|---|
| Title of host publication | Pharmacogenomics |
| Subtitle of host publication | Challenges and Opportunities in Therapeutic Implementation |
| Publisher | Elsevier |
| Pages | 1-44 |
| Number of pages | 44 |
| ISBN (Electronic) | 9780123919182 |
| ISBN (Print) | 9780123983039 |
| DOIs | |
| State | Published - Jan 1 2013 |
| Externally published | Yes |
Keywords
- drug metabolizing enzymes
- gene polymorphisms
- pharmacogenomics
- targets
- transporters
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Medicine