Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate

Hannah C. Cox, Claire Bellis, Rod A. Lea, Sharon Quinlan, Roger Hughes, Thomas Dyer, Jac Charlesworth, John Blangero, Lyn R. Griffiths

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective(s): An individual's risk of developing cardiovascular disease (CVD) is influenced by genetic factors. This study focussed on mapping genetic loci for CVD-risk traits in a unique population isolate derived from Norfolk Island. Methods: This investigation focussed on 377 individuals descended from the population founders. Principal component analysis was used to extract orthogonal components from 11 cardiovascular risk traits. Multipoint variance component methods were used to assess genome-wide linkage using SOLAR to the derived factors. A total of 285 of the 377 related individuals were informative for linkage analysis. Results: A total of 4 principal components accounting for 83% of the total variance were derived. Principal component 1 was loaded with body size indicators; principal component 2 with body size, cholesterol and triglyceride levels; principal component 3 with the blood pressures; and principal component 4 with LDL-cholesterol and total cholesterol levels. Suggestive evidence of linkage for principal component 2 (h2 = 0.35) was observed on chromosome 5q35 (LOD = 1.85; p = 0.0008). While peak regions on chromosome 10p11.2 (LOD = 1.27; p = 0.005) and 12q13 (LOD = 1.63; p = 0.003) were observed to segregate with principal components 1 (h2 = 0.33) and 4 (h2 = 0.42), respectively. Conclusion(s): This study investigated a number of CVD risk traits in a unique isolated population. Findings support the clustering of CVD risk traits and provide interesting evidence of a region on chromosome 5q35 segregating with weight, waist circumference, HDL-c and total triglyceride levels.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalHuman Heredity
Volume68
Issue number1
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Principal Component Analysis
Cardiovascular Diseases
Chromosomes
Body Size
Triglycerides
Melanesia
Cholesterol
Population
Genetic Loci
Waist Circumference
LDL Cholesterol
Cluster Analysis
Genome
Blood Pressure
Weights and Measures

Keywords

  • 5q35
  • CVD
  • Linkage analysis
  • Norfolk Island
  • Population isolate
  • Principal component

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Cox, H. C., Bellis, C., Lea, R. A., Quinlan, S., Hughes, R., Dyer, T., ... Griffiths, L. R. (2009). Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate. Human Heredity, 68(1), 55-64. https://doi.org/10.1159/000210449

Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate. / Cox, Hannah C.; Bellis, Claire; Lea, Rod A.; Quinlan, Sharon; Hughes, Roger; Dyer, Thomas; Charlesworth, Jac; Blangero, John; Griffiths, Lyn R.

In: Human Heredity, Vol. 68, No. 1, 04.2009, p. 55-64.

Research output: Contribution to journalArticle

Cox, HC, Bellis, C, Lea, RA, Quinlan, S, Hughes, R, Dyer, T, Charlesworth, J, Blangero, J & Griffiths, LR 2009, 'Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate', Human Heredity, vol. 68, no. 1, pp. 55-64. https://doi.org/10.1159/000210449
Cox, Hannah C. ; Bellis, Claire ; Lea, Rod A. ; Quinlan, Sharon ; Hughes, Roger ; Dyer, Thomas ; Charlesworth, Jac ; Blangero, John ; Griffiths, Lyn R. / Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate. In: Human Heredity. 2009 ; Vol. 68, No. 1. pp. 55-64.
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