Primary neoplastic transformation in vivo of xenogeneic skin grafts on nude mice

John W. Kreider, Gerald L. Bartlett, Francis E. Sharkey

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Rabbit skin was infected with Shope papilloma virus and grafted orthotopically to nude mice. Typical Shope rabbit papillomas developed in most of the grafts, but similarly treated nude mouse skin grafts were not altered. These results demonstrated that xenogeneic tissues retained susceptibility to oncogenic agents after transplantation to nude mice. The results also implied that it should be feasible to study carcinogenesis of human tissues in this system.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalCancer Research
Volume39
Issue number1
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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