Primary localized conjunctival amyloidosis presenting with unilateral ptosis

Purpose: Primary localized amyloidosis of eyelid is a localized type of amyloidosis without evidence of systemic involvement, which is a quite rare clinical condition. Here we report a case of primary localized amyloidosis of eyelid. Case report: A 40-year-old woman presented with a four-month history of swelling of the left upper eyelid resulting in a mechanical ptosis. The mass had a firm bony consistency. Ocular examination revealed a firm mass in upper lid connected to the tarsus. She had no sign or history of ocular inflammation. Homogenous eosinophilic deposits with extensive foci of calcification and ossification were visible In pathologic assessment, which was consistent with amyloidosis. All evaluations were negative for systemic amyloidosis. Conclusion: Primary localized amyloidosis may appear as a calcified and ossified tumoral mass.