Primary immunodeficiencies: Genetic risk factors for lymphoma

A. H. Filipovich, A. Mathur, D. Kamat, R. S. Shapiro

Research output: Contribution to journalArticlepeer-review

202 Scopus citations


It has been estimated that up to 25% of patients with certain genetically determined immunodeficiencies will develop tumors, primarily B-cell lymphomas, during their lifetime. Epstein-Barr virus appears to be an important cofactor in the development of lymphoproliferative disorders in patients with primary immunodeficiencies, as well as acquired immunodeficiencies. Additionally, host defects in immunoregulation and/or gene rearrangement, which are features of certain primary immunodeficiencies, probably contribute to the risk of lymphomagenesis in patients at risk.

Original languageEnglish (US)
Pages (from-to)5465s-5467s
JournalCancer Research
Issue number19 SUPPL.
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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