Abstract
It has been estimated that up to 25% of patients with certain genetically determined immunodeficiencies will develop tumors, primarily B-cell lymphomas, during their lifetime. Epstein-Barr virus appears to be an important cofactor in the development of lymphoproliferative disorders in patients with primary immunodeficiencies, as well as acquired immunodeficiencies. Additionally, host defects in immunoregulation and/or gene rearrangement, which are features of certain primary immunodeficiencies, probably contribute to the risk of lymphomagenesis in patients at risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5465s-5467s |
| Journal | Cancer Research |
| Volume | 52 |
| Issue number | 19 SUPPL. |
| State | Published - 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research