Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.)

Fabio Aloisio, Edward J. Dick, Gene B. Hubbard

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Primary neuroendocrine carcinomas of the liver have rarely been reported in humans and domestic animals, but not in non-human primates. Methods: We describe the morphologic and immunohistochemical features of a primary hepatic neuroendocrine carcinoma found in a 29-year-old female baboon. Results and conclusions: The neoplasm was characterized by multiple solid nodules that were multifocally distributed in the liver. Metastases were not observed. Histologically, the neoplasm was composed of cords and nests of epithelial cells arranged in a neuroendocrine pattern, occasionally forming glandular and rosette-like structures. On immunohistochemical evaluation, the neoplastic cells were immunopositive for pancytokeratin, chromogranin A, neuron-specific endolase, and synaptophysin and were negative for vimentin, S100 protein, glucagon, and insulin.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalJournal of medical primatology
Issue number1
StatePublished - 2009
Externally publishedYes


  • Endocrine
  • Liver
  • Non-human primate
  • Tumor

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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