Preweaning diet affects bile lipid composition and bile acid kinetics in infant baboons

E. M. Jackson, D. S. Lewis, C. A. McMahan, G. E. Mott

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We tested, with 14-wk-old baboons before weaning, the hypothesis that bile acid metabolism is differentially affected by breast feeding or by feeding formulas with a high polyunsaturated:saturated fatty acid ratio or with a low ratio, similar to that of breast milk. Bile lipid content, bile acid pool size, fractional turnover rate, synthetic rate and conjugate composition were measured in a single bile sample 9 d after an injection on d 1 of a mixture of [14C]cholic and [14C]chenodeoxycholic acids and an injection of a mixture of [3H]cholic acid and [3H]chenodeoxycholic acid on d 8. The principal biliary bile acid was chenodeoxycholic acid. The only difference in chenodeoxycholic acid metabolism among the infant diet groups was a lower chenodeoxycholic acid synthetic rate in baboons fed the low polyunsaturated:saturated formula compared with those fed the high polyunsaturated:saturated formula or breast-fed. Cholic acid metabolism was significantly affected by infant diet: breast-fed infants had a smaller cholic acid pool size, lower cholic acid percentage of total bile acids, higher cholic acid glycine:taurine conjugate ratio and larger cholic acid fractional turnover rate than formula-fed animals. The polyunsaturated:saturated fatty acid ratio in the formulas did not significantly affect these variables. These results show that differences in bile acid metabolism between breast- and formula-fed infant baboons are limited principally to cholic acid. These differences likely are due to factors other than fatty acid saturation.

Original languageEnglish (US)
Pages (from-to)1471-1479
Number of pages9
JournalJournal of Nutrition
Issue number9
StatePublished - 1993


  • baboon
  • bile acids
  • breast feeding
  • dietary fat
  • thyroid hormones

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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