Prewash total motile count is a poor predictor of live birth in intrauterine insemination cycles

Erin B. Mankus, Alan E. Holden, Paige M. Seeker, Jordan C. Kampschmidt, Jessica E. McLaughlin, Robert S. Schenken, Jennifer F. Knudtson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective: To determine whether there is a relationship between prewash total motile count and live births in couples undergoing IUI. Design: Retrospective review in a single academic center. Setting: Not applicable. Patient(s): Couples with infertility undergoing ovulation induction with IUI between 2010 and 2014. Intervention(s): Not applicable. Main Outcome Measure(s): Live births. Result(s): Our cohort included 310 women who underwent 655 IUI cycles with a cumulative live birth rate (LBR) per couple of 20% and an LBR per cycle of 10%. A analysis yielded no correlation between prewash total motile count (TMC) and live births. No live births occurred with TMC <2 million sperms. Age had a significant negative relationship to LBR. A receiver operating characteristic analysis comparing age and live births indicated a significant decline in live births for women >37 years (90% sensitivity, 70% specificity). The LBR per couple was decreased to 7% in women >37 years compared with 25% in women <37 years. Conclusion(s): Prewash TMC is a poor predictor of live birth. There were no live births with prewash TMC <2 million sperms. The LBR for women >37 years with IUI was significantly lower than women <37 years.

Original languageEnglish (US)
Pages (from-to)708-713
Number of pages6
JournalFertility and sterility
Issue number4
StatePublished - Apr 2019
Externally publishedYes


  • Total motile count
  • intrauterine insemination
  • live birth rate

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


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