Prevention Strategies to Combat Antimicrobial Resistance in Children in Resource-Limited Settings

Alejandro Diaz, Stella Antonara, Theresa Barton

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Purpose of Review: This review summarizes major antimicrobial-resistant pathogens emerging globally, including mechanisms of resistance and factors leading to acquisition of drug resistance in children. It further seeks to answer what steps should be taken in resource-limited settings to curb spread of these resistant pathogens. Recent Findings: Prevalence of drug resistance bacteria is increasing in children. Resistance is primarily driven by antibiotic overuse and misuse, amplified in developing countries by poor regulation and limited treatment options. The World Health Organization has outlined a comprehensive approach to reduce antimicrobial resistance. Data among children in the developing world are incomplete, but suggest this is a problem with huge healthcare costs. Summary: Prevention methods include classic sanitation, infection control, antimicrobial stewardship, as well as development of new technologies and improved surveillance. Future research should focus on population benefits, cost effectiveness of different approaches, and applying new technologies in a regulated way to the developing world.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalCurrent Tropical Medicine Reports
Issue number1
StatePublished - Mar 1 2018
Externally publishedYes


  • Antimicrobial resistance
  • Antimicrobial stewardship
  • Carbapenemase
  • ESBL
  • Infection control

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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