Prevention and treatment of drug-induced liver disease

K. V. Speeg, M. K. Bay

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Many drugs may cause liver damage; some damage is predictable, but most is not. The most important preventive measure is judicious drug use by the prescribing physician. Early recognition of hepatotoxicity and cessation of the offending agent is essential for treatment. The best example of a specific treatment for drug-induced liver disease is N-acetylcysteine treatment for acetaminophen hepatotoxicity. Many examples are cited of other attempts at treatment in animal models of drug-induced liver disease. If drug-induced liver disease leads to fulminant hepatic failure, intensive management of the resulting complications is required. Liver transplantation may be the only treatment option.

Original languageEnglish (US)
Pages (from-to)1047-1064
Number of pages18
JournalGastroenterology Clinics of North America
Issue number4
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Gastroenterology


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