Prevention and treatment of drug-induced liver disease

Kermit V Speeg, M. K. Bay

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Many drugs may cause liver damage; some damage is predictable, but most is not. The most important preventive measure is judicious drug use by the prescribing physician. Early recognition of hepatotoxicity and cessation of the offending agent is essential for treatment. The best example of a specific treatment for drug-induced liver disease is N-acetylcysteine treatment for acetaminophen hepatotoxicity. Many examples are cited of other attempts at treatment in animal models of drug-induced liver disease. If drug-induced liver disease leads to fulminant hepatic failure, intensive management of the resulting complications is required. Liver transplantation may be the only treatment option.

Original languageEnglish (US)
Pages (from-to)1047-1064
Number of pages18
JournalGastroenterology Clinics of North America
Volume24
Issue number4
StatePublished - 1995

Fingerprint

Chemical and Drug Induced Liver Injury
Therapeutics
Drug Prescriptions
Acute Liver Failure
Acetylcysteine
Acetaminophen
Liver Transplantation
Animal Models
Physicians
Liver
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prevention and treatment of drug-induced liver disease. / Speeg, Kermit V; Bay, M. K.

In: Gastroenterology Clinics of North America, Vol. 24, No. 4, 1995, p. 1047-1064.

Research output: Contribution to journalArticle

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