Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources

L. I. Gardner, M. P. Stern, S. M. Haffner, S. P. Gaskill, Helen P Hazuda, J. H. Relethford, C. W. Eifler

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

We have estimated the prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexican Americans and Anglos in three San Antonio neighborhoods. The age-adjusted NIDDM rates (both sexes pooled) for Mexican Americans were 14.5%, 10%, and 5% for residents of a low-income barrio, a middle-income transitional neighborhood, and a high-income suburb, respectively. In Mexican American women, though not in men, obesity also declined from barrio to surburbs. We have previously shown, however, that, although obesity is an important cause of NIDDM in Mexican Americans, there is a two- to fourfold excess in the rate of NIDDM in this ethnic group over and above that which can be attributed to obesity. We therefore speculated that genetic factors might also contribute to excess NIDDM in the ethnic group. The percent native American admixture of Mexican Americans as estimated from skin color measurements was 46% in the barrio, 27% in the transitional neighborhood, and 18% in the suburbs. The NIDDM rates in Mexican Americans thus paralleled the proportion of native American genes. Furthermore, the San Antonio Mexican American rates were intermediate between the NIDDM rates of 'full-blooded' Pima Indians (49.9%), who presumably have close to 100% native American genes, and the San Antonio Anglo population (3.0%) and the predominantly Anglo HANES II population (3.1%), both of which presumably have few if any native American genes. The association of genetic admixture with NIDDM rates suggests that much of the epidemic of NIDDM in Mexican Americans is confined to that part of the population with a substantial native American heritage.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalDiabetes
Volume33
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Gene Pool
North American Indians
Type 2 Diabetes Mellitus
Obesity
Ethnic Groups
Population
Genes
Skin Pigmentation
Potassium Iodide

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Gardner, L. I., Stern, M. P., Haffner, S. M., Gaskill, S. P., Hazuda, H. P., Relethford, J. H., & Eifler, C. W. (1984). Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources. Diabetes, 33(1), 86-92.

Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources. / Gardner, L. I.; Stern, M. P.; Haffner, S. M.; Gaskill, S. P.; Hazuda, Helen P; Relethford, J. H.; Eifler, C. W.

In: Diabetes, Vol. 33, No. 1, 1984, p. 86-92.

Research output: Contribution to journalArticle

Gardner, LI, Stern, MP, Haffner, SM, Gaskill, SP, Hazuda, HP, Relethford, JH & Eifler, CW 1984, 'Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources', Diabetes, vol. 33, no. 1, pp. 86-92.
Gardner LI, Stern MP, Haffner SM, Gaskill SP, Hazuda HP, Relethford JH et al. Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources. Diabetes. 1984;33(1):86-92.
Gardner, L. I. ; Stern, M. P. ; Haffner, S. M. ; Gaskill, S. P. ; Hazuda, Helen P ; Relethford, J. H. ; Eifler, C. W. / Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources. In: Diabetes. 1984 ; Vol. 33, No. 1. pp. 86-92.
@article{5cc2fa196442446aa25792e0d40a0cae,
title = "Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources",
abstract = "We have estimated the prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexican Americans and Anglos in three San Antonio neighborhoods. The age-adjusted NIDDM rates (both sexes pooled) for Mexican Americans were 14.5{\%}, 10{\%}, and 5{\%} for residents of a low-income barrio, a middle-income transitional neighborhood, and a high-income suburb, respectively. In Mexican American women, though not in men, obesity also declined from barrio to surburbs. We have previously shown, however, that, although obesity is an important cause of NIDDM in Mexican Americans, there is a two- to fourfold excess in the rate of NIDDM in this ethnic group over and above that which can be attributed to obesity. We therefore speculated that genetic factors might also contribute to excess NIDDM in the ethnic group. The percent native American admixture of Mexican Americans as estimated from skin color measurements was 46{\%} in the barrio, 27{\%} in the transitional neighborhood, and 18{\%} in the suburbs. The NIDDM rates in Mexican Americans thus paralleled the proportion of native American genes. Furthermore, the San Antonio Mexican American rates were intermediate between the NIDDM rates of 'full-blooded' Pima Indians (49.9{\%}), who presumably have close to 100{\%} native American genes, and the San Antonio Anglo population (3.0{\%}) and the predominantly Anglo HANES II population (3.1{\%}), both of which presumably have few if any native American genes. The association of genetic admixture with NIDDM rates suggests that much of the epidemic of NIDDM in Mexican Americans is confined to that part of the population with a substantial native American heritage.",
author = "Gardner, {L. I.} and Stern, {M. P.} and Haffner, {S. M.} and Gaskill, {S. P.} and Hazuda, {Helen P} and Relethford, {J. H.} and Eifler, {C. W.}",
year = "1984",
language = "English (US)",
volume = "33",
pages = "86--92",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "1",

}

TY - JOUR

T1 - Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources

AU - Gardner, L. I.

AU - Stern, M. P.

AU - Haffner, S. M.

AU - Gaskill, S. P.

AU - Hazuda, Helen P

AU - Relethford, J. H.

AU - Eifler, C. W.

PY - 1984

Y1 - 1984

N2 - We have estimated the prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexican Americans and Anglos in three San Antonio neighborhoods. The age-adjusted NIDDM rates (both sexes pooled) for Mexican Americans were 14.5%, 10%, and 5% for residents of a low-income barrio, a middle-income transitional neighborhood, and a high-income suburb, respectively. In Mexican American women, though not in men, obesity also declined from barrio to surburbs. We have previously shown, however, that, although obesity is an important cause of NIDDM in Mexican Americans, there is a two- to fourfold excess in the rate of NIDDM in this ethnic group over and above that which can be attributed to obesity. We therefore speculated that genetic factors might also contribute to excess NIDDM in the ethnic group. The percent native American admixture of Mexican Americans as estimated from skin color measurements was 46% in the barrio, 27% in the transitional neighborhood, and 18% in the suburbs. The NIDDM rates in Mexican Americans thus paralleled the proportion of native American genes. Furthermore, the San Antonio Mexican American rates were intermediate between the NIDDM rates of 'full-blooded' Pima Indians (49.9%), who presumably have close to 100% native American genes, and the San Antonio Anglo population (3.0%) and the predominantly Anglo HANES II population (3.1%), both of which presumably have few if any native American genes. The association of genetic admixture with NIDDM rates suggests that much of the epidemic of NIDDM in Mexican Americans is confined to that part of the population with a substantial native American heritage.

AB - We have estimated the prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexican Americans and Anglos in three San Antonio neighborhoods. The age-adjusted NIDDM rates (both sexes pooled) for Mexican Americans were 14.5%, 10%, and 5% for residents of a low-income barrio, a middle-income transitional neighborhood, and a high-income suburb, respectively. In Mexican American women, though not in men, obesity also declined from barrio to surburbs. We have previously shown, however, that, although obesity is an important cause of NIDDM in Mexican Americans, there is a two- to fourfold excess in the rate of NIDDM in this ethnic group over and above that which can be attributed to obesity. We therefore speculated that genetic factors might also contribute to excess NIDDM in the ethnic group. The percent native American admixture of Mexican Americans as estimated from skin color measurements was 46% in the barrio, 27% in the transitional neighborhood, and 18% in the suburbs. The NIDDM rates in Mexican Americans thus paralleled the proportion of native American genes. Furthermore, the San Antonio Mexican American rates were intermediate between the NIDDM rates of 'full-blooded' Pima Indians (49.9%), who presumably have close to 100% native American genes, and the San Antonio Anglo population (3.0%) and the predominantly Anglo HANES II population (3.1%), both of which presumably have few if any native American genes. The association of genetic admixture with NIDDM rates suggests that much of the epidemic of NIDDM in Mexican Americans is confined to that part of the population with a substantial native American heritage.

UR - http://www.scopus.com/inward/record.url?scp=0021358462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021358462&partnerID=8YFLogxK

M3 - Article

C2 - 6690348

AN - SCOPUS:0021358462

VL - 33

SP - 86

EP - 92

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 1

ER -