Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: The framingham heart study

Tulio Diaz, Michael J. Pencina, Emelia J. Benjamin, Jayashri Aragam, Deborah L. Fuller, Karol M. Pencina, Daniel Levy, Ramachandran S. Vasan

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The upper interventricular septum may be prominent in elderly individuals, a finding referred to as discrete upper septal thickening (DUST). We examined the prevalence, clinical and echocardiographic correlates, and prognostic significance of DUST in a community-based sample. We evaluated Framingham Study participants who underwent routine echocardiography. In 3562 Framingham Study participants (mean age 58 years, 57% women), DUST was observed in 52 participants. The clinical correlates of DUST were increasing age (odds ratio [OR] per 10 year increment 2.59, 95% confidence intervals [CI] 1.64-4.08) and systolic blood pressure (OR per SD increment 1.55, 95% CI 1.15-2.09). DUST was positively associated with left ventricular (LV) fractional shortening and mitral annular calcification but inversely with LV diastolic dimensions (P < 0.02 for all). On follow-up (mean 15 years), 732 individuals died (33 with DUST) and 560 experienced a cardiovascular disease (CVD) event (18 with DUST). Adjusting for cardiovascular risk factors, DUST was not associated with CVD or mortality risk (P > 0.30 for both). The follow-up component of our study suggests that DUST is not independently associated with adverse prognosis.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalEchocardiography
Volume26
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Keywords

  • Echocardiography
  • Epidemiology
  • Prognosis
  • Ventricular septum

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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