Pretreatment with GABA and modulatory ligands enhances GABA receptor binding

Gábor Maksay, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

GABA pretreatment at 37 ° C but not at 4 ° C enhanced subsequent [3H]GABA binding in a concentration-dependent manner (EC50 = 440 nM) by increasing the number of high and low affinity sites. The effect mediated by GABAA receptors was attenuated by bicuculline methiodide and picrotoxinin and potentiated by pentobarbial, flurazepam and Triton X-100. These results can be interpreted by the facilitated removal of endogenous substances and/or by a temperature-restricted conversion of the GABA receptor populations.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalEuropean Journal of Pharmacology
Volume104
Issue number1-2
DOIs
StatePublished - Sep 3 1984

Keywords

  • Endogenous substances
  • Enhancement of binding
  • GABA receptor complex
  • Ligand pretreatment
  • Receptor convertibility

ASJC Scopus subject areas

  • Pharmacology

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