Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs

J. W. Maas, S. H. Koslow, M. M. Katz, C. L. Bowden, R. L. Gibbons, P. E. Stokes, E. Robins, J. M. Davis

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Relationships between pretreatment neurotransmitter metabolite levels and response to imipramine and amitriptyline were studied in 104 depressed patients. Normal values for urinary norepinephrine and low values for urinary MHPG were associated with greater incidence of drug response in bipolar, but not unipolar, patients. For unipolar, but not bipolar, patients low CSF 5-HIAA and high urinary metanephrine values were associated with a greater incidence of drug response. These data indicate that the pretreatment functional state of catecholamine and serotonin systems is associated with type of response to drug treatment. The authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression.

Original languageEnglish (US)
Pages (from-to)1159-1171
Number of pages13
JournalAmerican Journal of Psychiatry
Volume141
Issue number10
StatePublished - 1984
Externally publishedYes

Fingerprint

Tricyclic Antidepressive Agents
Neurotransmitter Agents
Serotonin
Norepinephrine
Methoxyhydroxyphenylglycol
Metanephrine
Pharmaceutical Preparations
Hydroxyindoleacetic Acid
Amitriptyline
Imipramine
Incidence
Catecholamines
Reference Values
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Maas, J. W., Koslow, S. H., Katz, M. M., Bowden, C. L., Gibbons, R. L., Stokes, P. E., ... Davis, J. M. (1984). Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. American Journal of Psychiatry, 141(10), 1159-1171.

Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. / Maas, J. W.; Koslow, S. H.; Katz, M. M.; Bowden, C. L.; Gibbons, R. L.; Stokes, P. E.; Robins, E.; Davis, J. M.

In: American Journal of Psychiatry, Vol. 141, No. 10, 1984, p. 1159-1171.

Research output: Contribution to journalArticle

Maas, JW, Koslow, SH, Katz, MM, Bowden, CL, Gibbons, RL, Stokes, PE, Robins, E & Davis, JM 1984, 'Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs', American Journal of Psychiatry, vol. 141, no. 10, pp. 1159-1171.
Maas JW, Koslow SH, Katz MM, Bowden CL, Gibbons RL, Stokes PE et al. Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. American Journal of Psychiatry. 1984;141(10):1159-1171.
Maas, J. W. ; Koslow, S. H. ; Katz, M. M. ; Bowden, C. L. ; Gibbons, R. L. ; Stokes, P. E. ; Robins, E. ; Davis, J. M. / Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. In: American Journal of Psychiatry. 1984 ; Vol. 141, No. 10. pp. 1159-1171.
@article{7988951d83134e55aea463a09acda941,
title = "Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs",
abstract = "Relationships between pretreatment neurotransmitter metabolite levels and response to imipramine and amitriptyline were studied in 104 depressed patients. Normal values for urinary norepinephrine and low values for urinary MHPG were associated with greater incidence of drug response in bipolar, but not unipolar, patients. For unipolar, but not bipolar, patients low CSF 5-HIAA and high urinary metanephrine values were associated with a greater incidence of drug response. These data indicate that the pretreatment functional state of catecholamine and serotonin systems is associated with type of response to drug treatment. The authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression.",
author = "Maas, {J. W.} and Koslow, {S. H.} and Katz, {M. M.} and Bowden, {C. L.} and Gibbons, {R. L.} and Stokes, {P. E.} and E. Robins and Davis, {J. M.}",
year = "1984",
language = "English (US)",
volume = "141",
pages = "1159--1171",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "10",

}

TY - JOUR

T1 - Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs

AU - Maas, J. W.

AU - Koslow, S. H.

AU - Katz, M. M.

AU - Bowden, C. L.

AU - Gibbons, R. L.

AU - Stokes, P. E.

AU - Robins, E.

AU - Davis, J. M.

PY - 1984

Y1 - 1984

N2 - Relationships between pretreatment neurotransmitter metabolite levels and response to imipramine and amitriptyline were studied in 104 depressed patients. Normal values for urinary norepinephrine and low values for urinary MHPG were associated with greater incidence of drug response in bipolar, but not unipolar, patients. For unipolar, but not bipolar, patients low CSF 5-HIAA and high urinary metanephrine values were associated with a greater incidence of drug response. These data indicate that the pretreatment functional state of catecholamine and serotonin systems is associated with type of response to drug treatment. The authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression.

AB - Relationships between pretreatment neurotransmitter metabolite levels and response to imipramine and amitriptyline were studied in 104 depressed patients. Normal values for urinary norepinephrine and low values for urinary MHPG were associated with greater incidence of drug response in bipolar, but not unipolar, patients. For unipolar, but not bipolar, patients low CSF 5-HIAA and high urinary metanephrine values were associated with a greater incidence of drug response. These data indicate that the pretreatment functional state of catecholamine and serotonin systems is associated with type of response to drug treatment. The authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression.

UR - http://www.scopus.com/inward/record.url?scp=0021129115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021129115&partnerID=8YFLogxK

M3 - Article

VL - 141

SP - 1159

EP - 1171

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 10

ER -