Abstract
Superfused rat spinal cord synaptosomes were studied to determine if inhibitory serotonin (5-HT) receptors (autoreceptors) exist on spinal serotonergic nerve terminals. Exogenous 5-HT (1-50 nM) produced a concentration-dependent inhibition of K+-induced [3H]5-HT release but did not affect basal [3H]5-HT release. A 32-44% inhibition was produced,by 30 nM 5-HT. The inhibitory effect of 30 nM 5-HT was effectively antagonized by 100 nM metitepine, a 5-HT autoreceptor antagonist. The results provide evidence for the existence of 5-HT autoreceptors in rat spinal cord tissue.
Original language | English (US) |
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Pages (from-to) | 107-109 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 120 |
Issue number | 1 |
DOIs | |
State | Published - Jan 14 1986 |
Keywords
- Autoreceptors
- Metitepine
- Serotonin
- Spinal cord
ASJC Scopus subject areas
- Pharmacology