Presynaptic serotonin receptors regulate [3H]serotonin release from rat spinal cord synaptosomes

Kenneth A. Stauderman, David J. Jones

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Superfused rat spinal cord synaptosomes were studied to determine if inhibitory serotonin (5-HT) receptors (autoreceptors) exist on spinal serotonergic nerve terminals. Exogenous 5-HT (1-50 nM) produced a concentration-dependent inhibition of K+-induced [3H]5-HT release but did not affect basal [3H]5-HT release. A 32-44% inhibition was produced,by 30 nM 5-HT. The inhibitory effect of 30 nM 5-HT was effectively antagonized by 100 nM metitepine, a 5-HT autoreceptor antagonist. The results provide evidence for the existence of 5-HT autoreceptors in rat spinal cord tissue.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalEuropean Journal of Pharmacology
Volume120
Issue number1
DOIs
StatePublished - Jan 14 1986

Keywords

  • Autoreceptors
  • Metitepine
  • Serotonin
  • Spinal cord

ASJC Scopus subject areas

  • Pharmacology

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