Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension

J. T. Crofton, L. Share, B. C. Wang, R. E. Shade

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

To further characterize the role of vasopressin in DOC-salt hypertension, four groups of unilaterally nephrectomized rats were studied: control rats given no further treatment, rats treated with DOC and given 1% saline to drink, or rats treated with only DOC, or 1% saline. Only rats treated with DOC or DOC-salt became hypertensive. Control rats and rats treated with only DOC or 1% saline had similar pressor responses to exogenous vasopressin and angiotensin II. Within the DOC-salt group, two populations of rats were identified: one with normal pressor responsiveness to vasopressin, and one with markedly enhanced pressor responsiveness to vasopressin. Incidence of enhanced responsiveness increased with duration of treatment. Urinary excretion of vasopressin was elevated in the 1% saline and DOC-salt groups after 1 week of treatment, and in the DOC group after 4 weeks. However, the plasma vasopressin concentration was elevated only in the rats treated with both DOC and saline. It is suggested that vasopressin is essential for the expansion of blood volume in the early stages of DOC-salt hypertension, and functions as a direct pressor agent only in the later stages.

Original languageEnglish (US)
Pages (from-to)424-431
Number of pages8
JournalHypertension
Volume2
Issue number4
StatePublished - 1980
Externally publishedYes

Fingerprint

Vasopressins
Salts
Hypertension
Blood Volume
Angiotensin II
Incidence
Population

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Crofton, J. T., Share, L., Wang, B. C., & Shade, R. E. (1980). Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension. Hypertension, 2(4), 424-431.

Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension. / Crofton, J. T.; Share, L.; Wang, B. C.; Shade, R. E.

In: Hypertension, Vol. 2, No. 4, 1980, p. 424-431.

Research output: Contribution to journalArticle

Crofton, JT, Share, L, Wang, BC & Shade, RE 1980, 'Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension', Hypertension, vol. 2, no. 4, pp. 424-431.
Crofton JT, Share L, Wang BC, Shade RE. Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension. Hypertension. 1980;2(4):424-431.
Crofton, J. T. ; Share, L. ; Wang, B. C. ; Shade, R. E. / Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension. In: Hypertension. 1980 ; Vol. 2, No. 4. pp. 424-431.
@article{ea2d0b4c9a0e40e7828713d8da43c92b,
title = "Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension",
abstract = "To further characterize the role of vasopressin in DOC-salt hypertension, four groups of unilaterally nephrectomized rats were studied: control rats given no further treatment, rats treated with DOC and given 1{\%} saline to drink, or rats treated with only DOC, or 1{\%} saline. Only rats treated with DOC or DOC-salt became hypertensive. Control rats and rats treated with only DOC or 1{\%} saline had similar pressor responses to exogenous vasopressin and angiotensin II. Within the DOC-salt group, two populations of rats were identified: one with normal pressor responsiveness to vasopressin, and one with markedly enhanced pressor responsiveness to vasopressin. Incidence of enhanced responsiveness increased with duration of treatment. Urinary excretion of vasopressin was elevated in the 1{\%} saline and DOC-salt groups after 1 week of treatment, and in the DOC group after 4 weeks. However, the plasma vasopressin concentration was elevated only in the rats treated with both DOC and saline. It is suggested that vasopressin is essential for the expansion of blood volume in the early stages of DOC-salt hypertension, and functions as a direct pressor agent only in the later stages.",
author = "Crofton, {J. T.} and L. Share and Wang, {B. C.} and Shade, {R. E.}",
year = "1980",
language = "English (US)",
volume = "2",
pages = "424--431",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension

AU - Crofton, J. T.

AU - Share, L.

AU - Wang, B. C.

AU - Shade, R. E.

PY - 1980

Y1 - 1980

N2 - To further characterize the role of vasopressin in DOC-salt hypertension, four groups of unilaterally nephrectomized rats were studied: control rats given no further treatment, rats treated with DOC and given 1% saline to drink, or rats treated with only DOC, or 1% saline. Only rats treated with DOC or DOC-salt became hypertensive. Control rats and rats treated with only DOC or 1% saline had similar pressor responses to exogenous vasopressin and angiotensin II. Within the DOC-salt group, two populations of rats were identified: one with normal pressor responsiveness to vasopressin, and one with markedly enhanced pressor responsiveness to vasopressin. Incidence of enhanced responsiveness increased with duration of treatment. Urinary excretion of vasopressin was elevated in the 1% saline and DOC-salt groups after 1 week of treatment, and in the DOC group after 4 weeks. However, the plasma vasopressin concentration was elevated only in the rats treated with both DOC and saline. It is suggested that vasopressin is essential for the expansion of blood volume in the early stages of DOC-salt hypertension, and functions as a direct pressor agent only in the later stages.

AB - To further characterize the role of vasopressin in DOC-salt hypertension, four groups of unilaterally nephrectomized rats were studied: control rats given no further treatment, rats treated with DOC and given 1% saline to drink, or rats treated with only DOC, or 1% saline. Only rats treated with DOC or DOC-salt became hypertensive. Control rats and rats treated with only DOC or 1% saline had similar pressor responses to exogenous vasopressin and angiotensin II. Within the DOC-salt group, two populations of rats were identified: one with normal pressor responsiveness to vasopressin, and one with markedly enhanced pressor responsiveness to vasopressin. Incidence of enhanced responsiveness increased with duration of treatment. Urinary excretion of vasopressin was elevated in the 1% saline and DOC-salt groups after 1 week of treatment, and in the DOC group after 4 weeks. However, the plasma vasopressin concentration was elevated only in the rats treated with both DOC and saline. It is suggested that vasopressin is essential for the expansion of blood volume in the early stages of DOC-salt hypertension, and functions as a direct pressor agent only in the later stages.

UR - http://www.scopus.com/inward/record.url?scp=0019135796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019135796&partnerID=8YFLogxK

M3 - Article

C2 - 7399626

AN - SCOPUS:0019135796

VL - 2

SP - 424

EP - 431

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -