Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon

P. N. Fonjungo, E. N. Mpoudi, J. N. Torimiro, G. A. Alemnji, L. T. Eno, J. N. Nkengasong, F. Gao, M. Rayfield, T. M. Folks, D. Pieniazek, R. B. Lal

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations

    Abstract

    Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41.98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unliked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in tills population.

    Original languageEnglish (US)
    Pages (from-to)1319-1324
    Number of pages6
    JournalAIDS Research and Human Retroviruses
    Volume16
    Issue number13
    DOIs
    StatePublished - Sep 1 2000

    ASJC Scopus subject areas

    • Immunology
    • Virology
    • Infectious Diseases

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