Abstract
Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41.98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unliked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in tills population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1319-1324 |
| Number of pages | 6 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 16 |
| Issue number | 13 |
| DOIs | |
| State | Published - Sep 1 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. / Fonjungo, P. N.; Mpoudi, E. N.; Torimiro, J. N.; Alemnji, G. A.; Eno, L. T.; Nkengasong, J. N.; Gao, F.; Rayfield, M.; Folks, T. M.; Pieniazek, D.; Lal, R. B.
In: AIDS Research and Human Retroviruses, Vol. 16, No. 13, 01.09.2000, p. 1319-1324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon
AU - Fonjungo, P. N.
AU - Mpoudi, E. N.
AU - Torimiro, J. N.
AU - Alemnji, G. A.
AU - Eno, L. T.
AU - Nkengasong, J. N.
AU - Gao, F.
AU - Rayfield, M.
AU - Folks, T. M.
AU - Pieniazek, D.
AU - Lal, R. B.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41.98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unliked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in tills population.
AB - Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41.98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unliked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in tills population.
UR - http://www.scopus.com/inward/record.url?scp=0034284530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034284530&partnerID=8YFLogxK
U2 - 10.1089/08892220050117087
DO - 10.1089/08892220050117087
M3 - Article
C2 - 10957729
AN - SCOPUS:0034284530
VL - 16
SP - 1319
EP - 1324
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 13
ER -