Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon

P. N. Fonjungo, E. N. Mpoudi, J. N. Torimiro, G. A. Alemnji, L. T. Eno, J. N. Nkengasong, F. Gao, M. Rayfield, T. M. Folks, D. Pieniazek, R. B. Lal

Research output: Contribution to journalArticle

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Abstract

Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41.98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unliked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in tills population.

Original languageEnglish (US)
Pages (from-to)1319-1324
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume16
Issue number13
DOIs
StatePublished - Sep 1 2000
Externally publishedYes

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Cameroon
HIV-1
Cyprus
Cluster Analysis
Population

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Fonjungo, P. N., Mpoudi, E. N., Torimiro, J. N., Alemnji, G. A., Eno, L. T., Nkengasong, J. N., ... Lal, R. B. (2000). Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. AIDS Research and Human Retroviruses, 16(13), 1319-1324. https://doi.org/10.1089/08892220050117087

Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. / Fonjungo, P. N.; Mpoudi, E. N.; Torimiro, J. N.; Alemnji, G. A.; Eno, L. T.; Nkengasong, J. N.; Gao, F.; Rayfield, M.; Folks, T. M.; Pieniazek, D.; Lal, R. B.

In: AIDS Research and Human Retroviruses, Vol. 16, No. 13, 01.09.2000, p. 1319-1324.

Research output: Contribution to journalArticle

Fonjungo, PN, Mpoudi, EN, Torimiro, JN, Alemnji, GA, Eno, LT, Nkengasong, JN, Gao, F, Rayfield, M, Folks, TM, Pieniazek, D & Lal, RB 2000, 'Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon', AIDS Research and Human Retroviruses, vol. 16, no. 13, pp. 1319-1324. https://doi.org/10.1089/08892220050117087
Fonjungo PN, Mpoudi EN, Torimiro JN, Alemnji GA, Eno LT, Nkengasong JN et al. Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. AIDS Research and Human Retroviruses. 2000 Sep 1;16(13):1319-1324. https://doi.org/10.1089/08892220050117087
Fonjungo, P. N. ; Mpoudi, E. N. ; Torimiro, J. N. ; Alemnji, G. A. ; Eno, L. T. ; Nkengasong, J. N. ; Gao, F. ; Rayfield, M. ; Folks, T. M. ; Pieniazek, D. ; Lal, R. B. / Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. In: AIDS Research and Human Retroviruses. 2000 ; Vol. 16, No. 13. pp. 1319-1324.
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