Prepubertal exposure to arsenic(III) suppresses circulating insulin-like growth factor-1 (IGF-1) delaying sexual maturation in female rats

Michael P. Reilly, James C. Saca, Alina Hamilton, Rene F. Solano, Jesse R. Rivera, Wendy Whitehouse-Innis, Jason G. Parsons, Robert K. Dearth

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Arsenic (As) is a prevalent environmental toxin readily accessible for human consumption and has been identified as an endocrine disruptor. However, it is not known what impact As has on female sexual maturation. Therefore, in the present study, we investigated the effects of prepubertal exposure on mammary gland development and pubertal onset in female rats. Results showed that prepubertal exposure to 10. mg/kg of arsenite (As(III)) delayed vaginal opening (VO) and prepubertal mammary gland maturation. We determined that As accumulates in the liver, disrupts hepatocyte function and suppresses serum levels of the puberty related hormone insulin-like growth factor 1 (IGF-1) in prepubertal animals. Overall, this is the first study to show that prepubertal exposure to As(III) acts peripherally to suppress circulating levels of IGF-1 resulting in delayed sexual maturation. Furthermore, this study identifies a critical window of increased susceptibility to As(III) that may have a lasting impact on female reproductive function.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalReproductive Toxicology
Volume44
DOIs
StatePublished - Apr 2014

Keywords

  • Arsenic
  • Arsenite
  • Female puberty
  • Insulin-like growth factor-1 (IGF-1)
  • Mammary gland development
  • Pubertal delay
  • Reproductive toxicity

ASJC Scopus subject areas

  • Toxicology

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