Preoperative Systemic Therapy for Breast Cancer

Virginia Kaklamani, William J. Gradishar

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter presents a series of case studies with multiple choice questions and answers on preoperative systemic therapy for breast cancer. It commences with a discourse on preoperative endocrine approach reasonable in breast cancer patient, and ends with the radiation therapy necessary if a mastectomy is performed. The chapter also discusses on advantages of preoperative systemic therapy compared to postoperative adjuvant therapy, role of neo-adjuvant or primary chemotherapy for patients to achieve lumpectomy or breast conservation eligibility, and the optimal way to approach someone with HER2+ breast cancer requiring preoperative therapy.

Original languageEnglish (US)
Title of host publicationCancer Consult
Subtitle of host publicationExpertise for Clinical Practice
Number of pages8
ISBN (Electronic)9781118589199
ISBN (Print)9781118589212
StatePublished - Jun 20 2014
Externally publishedYes


  • Breast cancer
  • Chemotherapy
  • Postoperative adjuvant therapy
  • Preoperative systemic therapy

ASJC Scopus subject areas

  • Medicine(all)


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