Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery

Shannan M. Dickinson, Caitlin A. McIntyre, Juliana B. Schilsky, Kate A. Harrington, Scott R. Gerst, Jessica R. Flynn, Mithat Gonen, Marinela Capanu, Winston Wong, Sharon Lawrence, Peter J. Allen, Eileen M. O’Reilly, William R. Jarnagin, Michael I. D’Angelica, Vinod P. Balachandran, Jeffrey A. Drebin, T. Peter Kingham, Amber L. Simpson, Richard K. Do

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Purpose: To evaluate the associations between computed tomography (CT) imaging features extracted from the structured American Pancreatic Association (APA)/Society of Abdominal Radiology (SAR) template and overall survival in patients with resected pancreatic ductal adenocarcinoma (PDAC). Methods: This retrospective analysis included consecutive patients with PDAC who consented to genomic tumor testing and underwent preoperative imaging and curative intent surgical resection from December 2006 to July 2017. Two radiologists assessed preoperative CT imaging using the APA/SAR PDAC-reporting template. Univariable associations between overall survival and imaging variables were evaluated using Cox proportional hazards regression. Results: The study included 168 patients (66 years ± 11; 91 women). 126/168 patients (75%) received upfront surgical resection whereas 42/168 (25%) received neoadjuvant therapy prior to surgical resection. In the entire cohort, features associated with decreased overall survival were tumor arterial contact of any kind (hazard ratio (HR) 1.89, 95% CI 1.13–3.14, p = 0.020), tumor contact with the common hepatic artery (HR 2.33, 95% CI 1.35–4.04, p = 0.009), and portal vein deformity (HR 3.22, 95% CI 1.63–6.37, p = 0.003). In the upfront surgical group, larger tumor size was associated with decreased overall survival (HR 2.30, 95% CI 1.19–4.42, p = 0.013). In the neoadjuvant therapy group, the presence of venous collaterals was the only feature associated with decreased overall survival (HR 2.28, 95% CI 1.04–4.99, p = 0.042). Conclusion: The application of the APA/SAR pancreatic adenocarcinoma reporting template may identify predictors of survival that can aid in preoperative stratification of patients. Graphic abstract: [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)1607-1617
Number of pages11
JournalAbdominal Radiology
Volume46
Issue number4
DOIs
StatePublished - Apr 2021
Externally publishedYes

Keywords

  • Carcinoma
  • Neoadjuvant therapy
  • Neoplasm staging
  • Pancreatic carcinoma
  • Pancreatic ductal
  • Survival analysis
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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