Prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Songya Pang, Marilyn S. Pollack, Robert N. Marshall, La Donna Immken

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

CONGENITAL adrenal hyperplasia due to 21-hydroxylase deficiency is the most common cause of female pseudohermaphroditism. The severe classic disorder results in excess adrenal secretion of androgen from early fetal life, thereby causing the virilization of the external genitalia of affected female fetuses from the time of sexual differentiation onward. In human fetuses, sexual differentiation is believed to occur between 9 and 13 weeks of gestation.12 We can thus presume that the increased secretion of androgen by the adrenals in fetuses with congenital adrenal hyperplasia begins during or even before this critical period. Congenital adrenal hyperplasia is an HLA-linked autosomal recessive …

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalNew England Journal of Medicine
Volume322
Issue number2
DOIs
StatePublished - Jan 11 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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