TY - JOUR
T1 - Premature luteinizing hormone surges in menopausal gonadotropin-stimulated cycles in monkeys
T2 - Lack of initiation by progesterone
AU - Burns, W. N.
AU - Serafini, P. C.
AU - Riehl, R. M.
AU - Schenken, R. S.
N1 - Funding Information:
Received September 6, 1989; revised and accepted March 29, 1990. * Supported in part by grant P-30-10202 from the National Institutes of Health, Bethesda, Maryland. t Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio. *R eprint requests: William N. Burns, M.D., Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7836. § Huntington Reproductive Center, Huntington Memorial Hospital.
PY - 1990
Y1 - 1990
N2 - The occurrence of spontaneous luteinizing hormone (LH) surges in women receiving human menopausal gonadotropins (hMG) for in vitro fertilization-embryo transfer is a significant clinical problem. One hypothetical mechanism is that premature progesterone (P) secretion occurring in the high estradiol (E2) milieu produced by hMG triggers the spontaneous LH surge. To investigate this possibility, 11 rhesus and cynomolgus monkeys were stimulated with hMG. At maximal ovarian stimulation, monkeys were injected with 15 μg/kg P (n = 3), 30 μg/kg P (n = 3), or 1,000 IU human chorionic gonadotropin (hCG) (n = 5; controls). Blood for E2, P, and LH was drawn twice daily in the periovulatory period and daily before and after this period. Laparoscopy was performed after P or hCG injection. In the 6 monkeys receiving P, no LH surges were detected. Further, postinjection P profiles and laparoscopy showed no evidence of ovulation. Controls demonstrated laparoscopic and hormonal evidence of ovulation. These findings suggest that P does not trigger LH surges in hMG-stimulated cycles.
AB - The occurrence of spontaneous luteinizing hormone (LH) surges in women receiving human menopausal gonadotropins (hMG) for in vitro fertilization-embryo transfer is a significant clinical problem. One hypothetical mechanism is that premature progesterone (P) secretion occurring in the high estradiol (E2) milieu produced by hMG triggers the spontaneous LH surge. To investigate this possibility, 11 rhesus and cynomolgus monkeys were stimulated with hMG. At maximal ovarian stimulation, monkeys were injected with 15 μg/kg P (n = 3), 30 μg/kg P (n = 3), or 1,000 IU human chorionic gonadotropin (hCG) (n = 5; controls). Blood for E2, P, and LH was drawn twice daily in the periovulatory period and daily before and after this period. Laparoscopy was performed after P or hCG injection. In the 6 monkeys receiving P, no LH surges were detected. Further, postinjection P profiles and laparoscopy showed no evidence of ovulation. Controls demonstrated laparoscopic and hormonal evidence of ovulation. These findings suggest that P does not trigger LH surges in hMG-stimulated cycles.
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U2 - 10.1016/s0015-0282(16)53650-4
DO - 10.1016/s0015-0282(16)53650-4
M3 - Article
C2 - 2113486
AN - SCOPUS:0025358792
VL - 54
SP - 138
EP - 142
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 1
ER -