Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

D. W. Branch; D. J. Dudley; M. D. Mitchell

doi:10.1016/0140-6736(91)91572-C

Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

D. W. Branch, D. J. Dudley, M. D. Mitchell

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

To find out whether a serum factor in pre-eclamptic women is the cause of the raised serum endothelin concentrations associated with the disorder, the effect of serum from pre-eclamptic women on endothelin production by endothelial cells was compared with that of serum from pregnant and non-pregnant controls. The finding that pre-eclamptic serum suppresses endothelin production suggests that it contains a factor that might be part of a homoeostatic response to raised serum endothelin concentrations in pre-eclampsia.

Original language	English (US)
Pages (from-to)	943-945
Number of pages	3
Journal	The Lancet
Volume	337
Issue number	8747
DOIs	https://doi.org/10.1016/0140-6736(91)91572-C
State	Published - Apr 20 1991
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/0140-6736(91)91572-C

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@article{a74b7b39739b46288f34316535ea3b76,

title = "Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia",

abstract = "To find out whether a serum factor in pre-eclamptic women is the cause of the raised serum endothelin concentrations associated with the disorder, the effect of serum from pre-eclamptic women on endothelin production by endothelial cells was compared with that of serum from pregnant and non-pregnant controls. The finding that pre-eclamptic serum suppresses endothelin production suggests that it contains a factor that might be part of a homoeostatic response to raised serum endothelin concentrations in pre-eclampsia.",

author = "Branch, {D. W.} and Dudley, {D. J.} and Mitchell, {M. D.}",

note = "Funding Information: We thank Ms S. Bohnert, Mr D. Popovic, and Mrs S. Distel for technical assistance; Prof J. Bock for statistical analysis; Dr K. Skarvan for advice; Dr M. Ogletree for SQ-30741; and Dr R. Amstein for ketanserin. This work was supported by the Swiss National Research Foundation (no 32-25468.88; SCORE-grant no 3231-025150), the Swiss Cardiology Foundation, the Helmut Horten Foundation, and the Janssen Research Foundation (Beerse, Belgium).",

year = "1991",

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doi = "10.1016/0140-6736(91)91572-C",

language = "English (US)",

volume = "337",

pages = "943--945",

journal = "The Lancet",

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T1 - Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

AU - Branch, D. W.

AU - Dudley, D. J.

AU - Mitchell, M. D.

N1 - Funding Information: We thank Ms S. Bohnert, Mr D. Popovic, and Mrs S. Distel for technical assistance; Prof J. Bock for statistical analysis; Dr K. Skarvan for advice; Dr M. Ogletree for SQ-30741; and Dr R. Amstein for ketanserin. This work was supported by the Swiss National Research Foundation (no 32-25468.88; SCORE-grant no 3231-025150), the Swiss Cardiology Foundation, the Helmut Horten Foundation, and the Janssen Research Foundation (Beerse, Belgium).

PY - 1991/4/20

Y1 - 1991/4/20

N2 - To find out whether a serum factor in pre-eclamptic women is the cause of the raised serum endothelin concentrations associated with the disorder, the effect of serum from pre-eclamptic women on endothelin production by endothelial cells was compared with that of serum from pregnant and non-pregnant controls. The finding that pre-eclamptic serum suppresses endothelin production suggests that it contains a factor that might be part of a homoeostatic response to raised serum endothelin concentrations in pre-eclampsia.

AB - To find out whether a serum factor in pre-eclamptic women is the cause of the raised serum endothelin concentrations associated with the disorder, the effect of serum from pre-eclamptic women on endothelin production by endothelial cells was compared with that of serum from pregnant and non-pregnant controls. The finding that pre-eclamptic serum suppresses endothelin production suggests that it contains a factor that might be part of a homoeostatic response to raised serum endothelin concentrations in pre-eclampsia.

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JO - The Lancet

JF - The Lancet

IS - 8747

ER -

Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

Abstract

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