Prehospital Transfusion of Low-Titer O + Whole Blood for Severe Maternal Hemorrhage: A Case Report

Ryan Newberry, C. J. Winckler, Ryan Luellwitz, Leslie Greebon, Elly M Xenakis, William Bullock, Michael Stringfellow, Julian Mapp

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Introduction: Beginning in 2017, multiple stakeholders within the Southwest Texas Regional Advisory Council for Trauma collaborated to incorporate cold-stored low-titer O RhD-positive whole blood (LTO + WB) into all phases of their trauma system, including the prehospital phase of care. Although the program was initially focused on trauma resuscitation, it was expanded to included non-traumatic hemorrhagic shock patients that may benefit from whole blood resuscitation. Case Report: We report the case of a patient with severe maternal hemorrhage secondary to placenta accreta who received a prehospital transfusion of LTO + WB. We believe this to be the first reported case of post-partum hemorrhage resuscitated out of hospital with whole blood. Discussion: This case highlights the potential benefits of a prehospital whole blood program as well as the controversy surrounding a LTO + WB program that includes females of childbearing age.

Original languageEnglish (US)
Pages (from-to)566-575
Number of pages10
JournalPrehospital Emergency Care
Issue number4
StatePublished - Jul 3 2020


  • low-titer O + whole blood transfusion
  • maternal hemorrhage
  • post-partum hemorrhage
  • whole blood transfusion

ASJC Scopus subject areas

  • Emergency
  • Emergency Medicine


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