Prehospital low-titer cold-stored whole blood: Philosophy for ubiquitous utilization of O-positive product for emergency use in hemorrhage due to injury

Ashley C. McGinity, Caroline S. Zhu, Leslie Greebon, Elly Xenakis, Elizabeth Waltman, Eric Epley, Danielle Cobb, Rachelle Jonas, Susannah E. Nicholson, Brian J Eastridge, Ronald M. Stewart, Donald H. Jenkins

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The mortality from hemorrhage in trauma patients remains high. Early balanced resuscitation improves survival. These truths, balanced with the availability of local resources and our goals for positive regional impact, were the foundation for the development of our prehospital whole blood initiative-using low-titer cold-stored O RhD-positive whole blood. The main concern with use of RhD-positive blood is the potential development of isoimmunization in RhD-negative patients. We used our retrospective massive transfusion protocol (MTP) data to analyze the anticipated risk of this change in practice. In 30 months, of 124 total MTP patients, only one female of childbearing age that received an MTP was RhD-negative. With the risk of isoimmunization very low and the benefit of increased resources for the early administration of balanced resuscitation high, we determined that the utilization of low-titer cold-stored O RhD-positive whole blood would be safe and best serve our community.

Original languageEnglish (US)
Pages (from-to)S115-S119
JournalThe journal of trauma and acute care surgery
Volume84
Issue number6S Suppl 1
DOIs
StatePublished - Jun 1 2018

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ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

McGinity, A. C., Zhu, C. S., Greebon, L., Xenakis, E., Waltman, E., Epley, E., Cobb, D., Jonas, R., Nicholson, S. E., Eastridge, B. J., Stewart, R. M., & Jenkins, D. H. (2018). Prehospital low-titer cold-stored whole blood: Philosophy for ubiquitous utilization of O-positive product for emergency use in hemorrhage due to injury. The journal of trauma and acute care surgery, 84(6S Suppl 1), S115-S119. https://doi.org/10.1097/TA.0000000000001905