Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity

N. Schlabritz-Loutsevitch, K. Apostolakis-Kyrus, R. Krutilina, G. Hubbard, M. Kocak, Z. Janjetovic, S. Sathanandam, A. T. Slominski, G. Mari, E. Dick

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. Methods: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified. Results: LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03). Conclusion: Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalJournal of medical primatology
Volume45
Issue number6
DOIs
StatePublished - Dec 1 2016

Keywords

  • maternal obesity
  • non-human primate
  • vascular remodeling

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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