Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study

E. Serap Monkul, Koji Matsuo, Mark A. Nicoletti, Nicole Dierschke, John P. Hatch, Manish Dalwani, Paolo Brambilla, Sheila Caetano, Roberto B. Sassi, Allan G. Mallinger, Jair C. Soares

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age = 25.9 ± 10.0 years) were studied. 3D SPGR MRIs (TR = 25 ms, TE = 5 ms, slice-thickness = 1.5 mm) were acquired using a 1.5 T GE Signa Imaging System, at baseline and after 4 weeks of lithium administration at therapeutically relevant doses. Optimized voxel-based morphometry (VBM) analyses were conducted. Left and right dorsolateral prefrontal cortex and left anterior cingulate gray matter volumes increased significantly following lithium administration. Total white matter volume was increased, whereas total brain volume and total gray matter volume were not significantly changed following 4 weeks of lithium. Lithium treatment resulted in prefrontal regional gray matter volume increases in healthy volunteers, as well as increases in total white matter volume. Whether these changes are mediated by neurotrophic/neuroprotective or osmotic effects remains unknown.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalNeuroscience Letters
Volume429
Issue number1
DOIs
StatePublished - Dec 11 2007

Keywords

  • Cingulate gyrus
  • Lithium
  • Neuroimaging
  • Neuroprotection
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)

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    Monkul, E. S., Matsuo, K., Nicoletti, M. A., Dierschke, N., Hatch, J. P., Dalwani, M., Brambilla, P., Caetano, S., Sassi, R. B., Mallinger, A. G., & Soares, J. C. (2007). Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study. Neuroscience Letters, 429(1), 7-11. https://doi.org/10.1016/j.neulet.2007.09.074