TY - JOUR
T1 - Prefrontal cognitive dysfunction following brainstem lesion
AU - Salgado, João Vinícius
AU - Costa-Silva, Melissa
AU - Malloy-Diniz, Leandro Fernandes
AU - Siqueira, José Maurício
AU - Teixeira, Antônio Lúcio
PY - 2007/5
Y1 - 2007/5
N2 - Prefrontal cortex (PFC) dysfunction can lead to impairment in planning and behavioral inhibition, as well as personality changes. As ascending monoaminergic brainstem systems modulate PFC functioning, it is possible that lesions in the brainstem lead to symptoms similar to prefrontal dysfunction. A 29-year-old man developed several cognitive and behavioral symptoms after neurosurgery for resection of a pilocytic astrocytoma in the pontine-mesencephalic area. A careful analysis of symptoms indicated PFC dysfunction that could be attributed to lesions in the ascending monoaminergic brainstem systems. Interestingly, the cognitive symptoms improved after treatment with methylphenidate, which is a drug that modules catecholaminergic neurotransmission, thereby supporting this hypothesis. This is a unique case of PFC dysfunction that may be related to post-operative lesion of the catecholaminergic nuclei in the brainstem.
AB - Prefrontal cortex (PFC) dysfunction can lead to impairment in planning and behavioral inhibition, as well as personality changes. As ascending monoaminergic brainstem systems modulate PFC functioning, it is possible that lesions in the brainstem lead to symptoms similar to prefrontal dysfunction. A 29-year-old man developed several cognitive and behavioral symptoms after neurosurgery for resection of a pilocytic astrocytoma in the pontine-mesencephalic area. A careful analysis of symptoms indicated PFC dysfunction that could be attributed to lesions in the ascending monoaminergic brainstem systems. Interestingly, the cognitive symptoms improved after treatment with methylphenidate, which is a drug that modules catecholaminergic neurotransmission, thereby supporting this hypothesis. This is a unique case of PFC dysfunction that may be related to post-operative lesion of the catecholaminergic nuclei in the brainstem.
KW - Brainstem
KW - Cognition
KW - Methylphenidate
KW - Monoaminergic systems
KW - Prefrontal cortex
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U2 - 10.1016/j.clineuro.2007.01.002
DO - 10.1016/j.clineuro.2007.01.002
M3 - Article
C2 - 17275997
AN - SCOPUS:33947301628
SN - 0303-8467
VL - 109
SP - 379
EP - 382
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 4
ER -