Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting.

R. J. Leach, A. N. Magewu, J. D. Buckley, W. F. Benedict, C. Rother, A. L. Murphree, S. Griegel, M. F. Rajewsky, P. A. Jones

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The origins of the initial mutations in sporadic retinoblastoma were explored using polymorphic markers from chromosome 13q. The paternal chromosome was maintained in 3 of 3 informative bilateral tumors which had undergone reduction to homozygosity for regions of this chromosome. The paternal chromosome was maintained in 7 of 8 informative unilateral tumors which likewise demonstrated a reduction of homozygosity. These data are in contrast to previously published studies of chromosome retention in unilateral retinoblastoma [Dryja, T. P., Mukai, S., Petersen, R., Rapaport, J. M., Walton, D., and Yandel, D. W. Nature (Lond.), 339: 556-558, 1989; Zhu, Z., Dunn, J. M., Phillips, R. A., Goddard, A. D., Paton, K. E., Becker, A., and Gallie, B. L. Nature (Lond.), 340: 312-313, 1989] and provide the first evidence that genomic imprinting may play a role in this disease.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalCell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Volume1
Issue number9
StatePublished - Sep 1990
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Leach, R. J., Magewu, A. N., Buckley, J. D., Benedict, W. F., Rother, C., Murphree, A. L., Griegel, S., Rajewsky, M. F., & Jones, P. A. (1990). Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1(9), 401-406.