Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity

Ahmad R. Hariri, Sarah M. Brown, Douglas E. Williamson, Janine D. Flory, Harriet De Wit, Stephen B. Manuck

Research output: Contribution to journalArticle

329 Citations (Scopus)

Abstract

Discounting future outcomes as a function of their deferred availability underlies much of human decision making. Discounting, or preference for immediate over delayed rewards of larger value, is often associated with impulsivity and is a risk factor for addictive disorders such as pathological gambling, cigarette smoking, and drug and alcohol abuse. The ventral striatum (VS) is involved in mediating behavioral responses and physiological states associated with reward, and dysregulation of the VS contributes to addiction, perhaps by affecting impulsive decision-making. Behavioral tests of delay discounting (DD), which index preference for smaller immediate over larger delayed rewards, covary with impulsive tendencies in humans. In the current study, we examined the relationship between individual differences in DD, measured in a behavioral assessment, and VS activity measured with blood oxygenation level-dependent functional magnetic resonance imaging, in 45 adult volunteers. VS activity was determined using a task involving positive and negative feedback with monetary reward. Analyses revealed that individual differences in DD correlate positively with magnitude of VS activation in response to both positive and negative feedback, compared with a no-feedback control condition. Variability in DD was also associated with differential VS activation in response to positive, compared with negative, feedback. Collectively, our results suggest that increased preference for smaller immediate over larger delayed rewards reflects both a relatively indiscriminate and hyper-reactive VS circuitry. They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction.

Original languageEnglish (US)
Pages (from-to)13213-13217
Number of pages5
JournalJournal of Neuroscience
Volume26
Issue number51
DOIs
StatePublished - Dec 20 2006

Fingerprint

Corpus Striatum
Reward
Individuality
Decision Making
Gambling
Impulsive Behavior
Ventral Striatum
Alcoholism
Substance-Related Disorders
Volunteers
Smoking
Magnetic Resonance Imaging
Delay Discounting

Keywords

  • Delay discounting
  • Impulsivity
  • Individual differences
  • Reward sensitivity
  • Ventral striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., De Wit, H., & Manuck, S. B. (2006). Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. Journal of Neuroscience, 26(51), 13213-13217. https://doi.org/10.1523/JNEUROSCI.3446-06.2006

Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. / Hariri, Ahmad R.; Brown, Sarah M.; Williamson, Douglas E.; Flory, Janine D.; De Wit, Harriet; Manuck, Stephen B.

In: Journal of Neuroscience, Vol. 26, No. 51, 20.12.2006, p. 13213-13217.

Research output: Contribution to journalArticle

Hariri, AR, Brown, SM, Williamson, DE, Flory, JD, De Wit, H & Manuck, SB 2006, 'Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity', Journal of Neuroscience, vol. 26, no. 51, pp. 13213-13217. https://doi.org/10.1523/JNEUROSCI.3446-06.2006
Hariri, Ahmad R. ; Brown, Sarah M. ; Williamson, Douglas E. ; Flory, Janine D. ; De Wit, Harriet ; Manuck, Stephen B. / Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. In: Journal of Neuroscience. 2006 ; Vol. 26, No. 51. pp. 13213-13217.
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