TY - JOUR
T1 - Preference-based quality of life measurement in patients with cervical spondylotic myelopathy
AU - King, Joseph T.
AU - Tsevat, Joel
AU - Moossy, John J.
AU - Roberts, Mark S.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - Study Design. Prospective cross-sectional observational cohort study. Objectives. To assess the performance of preference-based quality of life (QOL) instruments in patients with cervical spondylotic myelopathy (CSM). Summary of Background Data. Generic health status instruments (e.g., SF-36) or disease-specific health status measures (e.g., myelopathy scales) are typically used to measure QOL in patients with CSM; however, these instruments only examine a limited number of domains that contribute to QOL. An alternative is preference-based QOL methods, which integrate all factors contributing to QOL and provide a comprehensive individualized measure of how patients value their current health state. Methods. We used four preference-based QOL methods to measure QOL in a cohort of 79 patients with CSM: 1) visual analogue scale, 2) standard gamble, 3) time trade-off, and 4) willingness to pay. We measured health status with the SF-36 and with CSM disease-specific scales devised by Nurick, Harsh, Cooper, and the Japanese Orthopedic Association. We used multivariate linear regression techniques to examine the relationships between preference-based QOL, generic health status, CSM disease-specific health status, and patient characteristics. Results. Median preference-based QOL measurements for the CSM cohort were as follows: visual analogue scale, 0.50; standard gamble, 0.79; time trade-off, 0.75, and willingness to pay, $38,256. Preference-based QOL was not well explained by generic health status, CSM disease-specific health status, or patient characteristics, as shown by regression models that were unable to account more than 21% of the variation in preference-based QOL (R 2 ≤ 0.21). Conclusions. Preference-based QOL in patients with CSM is poorly correlated with generic health status, CSM disease-specific health status, or patient characteristics. Studies of CSM and other spine diseases should consider incorporating preference-based QOL measures for a fuller evaluation of the impact of spine disease and its treatment on QOL.
AB - Study Design. Prospective cross-sectional observational cohort study. Objectives. To assess the performance of preference-based quality of life (QOL) instruments in patients with cervical spondylotic myelopathy (CSM). Summary of Background Data. Generic health status instruments (e.g., SF-36) or disease-specific health status measures (e.g., myelopathy scales) are typically used to measure QOL in patients with CSM; however, these instruments only examine a limited number of domains that contribute to QOL. An alternative is preference-based QOL methods, which integrate all factors contributing to QOL and provide a comprehensive individualized measure of how patients value their current health state. Methods. We used four preference-based QOL methods to measure QOL in a cohort of 79 patients with CSM: 1) visual analogue scale, 2) standard gamble, 3) time trade-off, and 4) willingness to pay. We measured health status with the SF-36 and with CSM disease-specific scales devised by Nurick, Harsh, Cooper, and the Japanese Orthopedic Association. We used multivariate linear regression techniques to examine the relationships between preference-based QOL, generic health status, CSM disease-specific health status, and patient characteristics. Results. Median preference-based QOL measurements for the CSM cohort were as follows: visual analogue scale, 0.50; standard gamble, 0.79; time trade-off, 0.75, and willingness to pay, $38,256. Preference-based QOL was not well explained by generic health status, CSM disease-specific health status, or patient characteristics, as shown by regression models that were unable to account more than 21% of the variation in preference-based QOL (R 2 ≤ 0.21). Conclusions. Preference-based QOL in patients with CSM is poorly correlated with generic health status, CSM disease-specific health status, or patient characteristics. Studies of CSM and other spine diseases should consider incorporating preference-based QOL measures for a fuller evaluation of the impact of spine disease and its treatment on QOL.
KW - Cervical vertebrae
KW - Health status
KW - Outcomes assessment (health care)
KW - Quality of life
KW - Spinal stenosis
UR - http://www.scopus.com/inward/record.url?scp=2542440524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542440524&partnerID=8YFLogxK
U2 - 10.1097/00007632-200406010-00018
DO - 10.1097/00007632-200406010-00018
M3 - Article
C2 - 15167668
AN - SCOPUS:2542440524
VL - 29
SP - 1271
EP - 1280
JO - Spine
JF - Spine
SN - 0362-2436
IS - 11
ER -