Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes

Tea Kaartokallio, A. Inkeri Lokki, Hanna Peterson, Katja Kivinen, Leena Hiltunen, Elina Salmela, Tuuli Lappalainen, Paula Maanselkä, Sanna Heino, Sakari Knuutila, Ayat Sayed, Lucilla Poston, Shaun P. Brennecke, Matthew P. Johnson, Linda Morgan, Eric K. Moses, Juha Kere, Hannele Laivuori

Research output: Contribution to journalArticle

Abstract

Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p ≤ 0.024 uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key messagesChromosome 9p21 is not associated with preeclampsia.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAnnals of Medicine
DOIs
StateAccepted/In press - Apr 22 2016
Externally publishedYes

Keywords

  • CAD
  • case-control study
  • chromosome 9
  • Preeclampsia

ASJC Scopus subject areas

  • Medicine(all)

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    Kaartokallio, T., Lokki, A. I., Peterson, H., Kivinen, K., Hiltunen, L., Salmela, E., Lappalainen, T., Maanselkä, P., Heino, S., Knuutila, S., Sayed, A., Poston, L., Brennecke, S. P., Johnson, M. P., Morgan, L., Moses, E. K., Kere, J., & Laivuori, H. (Accepted/In press). Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. Annals of Medicine, 1-7. https://doi.org/10.1080/07853890.2016.1174877