Predominance of 2-hydroxymelatonin over melatonin in plants

Yeong Byeon, Dun Xian Tan, Russel J. Reiter, Kyoungwhan Back

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


The cloning of the gene encoding melatonin 2-hydroxylase (M2H), which is responsible for the synthesis of 2-hydroxymelatonin, has expanded the study of melatonin metabolism in plants. Kinetic analysis of M2H enzymatic activity demonstrated that the catalytic efficiency of M2H is much higher than those of other melatonin biosynthetic enzymes such as serotonin N-acetyltransferase (SNAT) and N-acetylserotonin O-methyltransferase (ASMT), suggesting that melatonin metabolism is rapid in plants. To test this prediction, we selected 24 plant species belonging to 16 families and quantified the levels of melatonin and 2-hydroxymelatonin using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The melatonin levels in most of the species were

Original languageEnglish (US)
Pages (from-to)448-454
Number of pages7
JournalJournal of Pineal Research
Issue number4
StatePublished - Nov 1 2015
Externally publishedYes


  • 2-hydroxymelatonin
  • melatonin
  • melatonin 2-hydroxylase
  • metabolic flow

ASJC Scopus subject areas

  • Endocrinology


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