Predictors of response to divalproex and lithium

C. L. Bowden

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Predictors of response to mood stabilizers are of interest to psychiatrists because patients want and deserve prompt improvement, need to preserve limited hospital benefits, and desire agents that are both efficacious and free of adverse effects. Clinically practical guidelines for the likelihood of lithium responsiveness include mild and uncomplicated illness, pure tannic symptomatology, prior response to lithium, and infrequent episodes. Divalproex has a broader spectrum of responders and has approximately equal benefit for patients with pure mania as for those with several forms of bipolar disorder that respond poorly to lithium (e.g., mixed mania, rapid cycling, comorbid substance abuse, and secondary bipolar disorder). Carbamazepine may be effective in patients who failed to respond to lithium and is more likely to be effective as part of combined drug therapy than as monotherapy. This review points out that, although the number of firm findings regarding predictors of response and the features associated with response are few, many of these can be combined with other general clinical information about the status of the patient to provide a guide to treatment selection and implementation of a therapeutic regimen.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalJournal of Clinical Psychiatry
Volume56
Issue number3 SUPPL.
StatePublished - 1995

Fingerprint

Valproic Acid
Bipolar Disorder
Lithium
Carbamazepine
Substance-Related Disorders
Psychiatry
Guidelines
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Predictors of response to divalproex and lithium. / Bowden, C. L.

In: Journal of Clinical Psychiatry, Vol. 56, No. 3 SUPPL., 1995, p. 25-30.

Research output: Contribution to journalArticle

Bowden, CL 1995, 'Predictors of response to divalproex and lithium', Journal of Clinical Psychiatry, vol. 56, no. 3 SUPPL., pp. 25-30.
Bowden, C. L. / Predictors of response to divalproex and lithium. In: Journal of Clinical Psychiatry. 1995 ; Vol. 56, No. 3 SUPPL. pp. 25-30.
@article{4862806847764bf8a07b45cf8a81c7ed,
title = "Predictors of response to divalproex and lithium",
abstract = "Predictors of response to mood stabilizers are of interest to psychiatrists because patients want and deserve prompt improvement, need to preserve limited hospital benefits, and desire agents that are both efficacious and free of adverse effects. Clinically practical guidelines for the likelihood of lithium responsiveness include mild and uncomplicated illness, pure tannic symptomatology, prior response to lithium, and infrequent episodes. Divalproex has a broader spectrum of responders and has approximately equal benefit for patients with pure mania as for those with several forms of bipolar disorder that respond poorly to lithium (e.g., mixed mania, rapid cycling, comorbid substance abuse, and secondary bipolar disorder). Carbamazepine may be effective in patients who failed to respond to lithium and is more likely to be effective as part of combined drug therapy than as monotherapy. This review points out that, although the number of firm findings regarding predictors of response and the features associated with response are few, many of these can be combined with other general clinical information about the status of the patient to provide a guide to treatment selection and implementation of a therapeutic regimen.",
author = "Bowden, {C. L.}",
year = "1995",
language = "English (US)",
volume = "56",
pages = "25--30",
journal = "The Journal of clinical psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "3 SUPPL.",

}

TY - JOUR

T1 - Predictors of response to divalproex and lithium

AU - Bowden, C. L.

PY - 1995

Y1 - 1995

N2 - Predictors of response to mood stabilizers are of interest to psychiatrists because patients want and deserve prompt improvement, need to preserve limited hospital benefits, and desire agents that are both efficacious and free of adverse effects. Clinically practical guidelines for the likelihood of lithium responsiveness include mild and uncomplicated illness, pure tannic symptomatology, prior response to lithium, and infrequent episodes. Divalproex has a broader spectrum of responders and has approximately equal benefit for patients with pure mania as for those with several forms of bipolar disorder that respond poorly to lithium (e.g., mixed mania, rapid cycling, comorbid substance abuse, and secondary bipolar disorder). Carbamazepine may be effective in patients who failed to respond to lithium and is more likely to be effective as part of combined drug therapy than as monotherapy. This review points out that, although the number of firm findings regarding predictors of response and the features associated with response are few, many of these can be combined with other general clinical information about the status of the patient to provide a guide to treatment selection and implementation of a therapeutic regimen.

AB - Predictors of response to mood stabilizers are of interest to psychiatrists because patients want and deserve prompt improvement, need to preserve limited hospital benefits, and desire agents that are both efficacious and free of adverse effects. Clinically practical guidelines for the likelihood of lithium responsiveness include mild and uncomplicated illness, pure tannic symptomatology, prior response to lithium, and infrequent episodes. Divalproex has a broader spectrum of responders and has approximately equal benefit for patients with pure mania as for those with several forms of bipolar disorder that respond poorly to lithium (e.g., mixed mania, rapid cycling, comorbid substance abuse, and secondary bipolar disorder). Carbamazepine may be effective in patients who failed to respond to lithium and is more likely to be effective as part of combined drug therapy than as monotherapy. This review points out that, although the number of firm findings regarding predictors of response and the features associated with response are few, many of these can be combined with other general clinical information about the status of the patient to provide a guide to treatment selection and implementation of a therapeutic regimen.

UR - http://www.scopus.com/inward/record.url?scp=0028951910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028951910&partnerID=8YFLogxK

M3 - Article

C2 - 7883739

AN - SCOPUS:0028951910

VL - 56

SP - 25

EP - 30

JO - The Journal of clinical psychiatry

JF - The Journal of clinical psychiatry

SN - 0160-6689

IS - 3 SUPPL.

ER -